通过视频头部脉冲测试对静脉功能的定量评估以及在基斯普拉基化学辐射期间引起静脉肌性潜力
Natsuki Takada1,2, Hiroshi Okuda1, Hirofumi Shibata1
1Department of Otolaryngology-Head and Neck Surgery, Gifu University Graduate School of Medicine, Gifu, Japan.
概括
西斯普拉丁治疗显著影响前庭功能,导致宫前庭引起的肌性潜能幅度下降和听力恶化. 较高的思普拉丁剂量与减少的前庭眼反射增益相关,表明潜在的前庭功能障碍.
科学领域:
- 耳毒性研究研究
- 神经科学是一个神经科学.
- 静脉系统疾病 静脉系统疾病
背景情况:
- 西斯是一种广泛使用的化疗剂.
- 静脉和听觉功能可能会受到西斯普拉丁治疗的影响.
- 早期检测西斯胺诱导的耳毒性是至关重要的.
研究的目的:
- 为了评估西斯丁对前庭功能的影响.
- 为了评估治疗cisplatin后听力敏度和前体参数的变化.
主要方法:
- 对28名接受基于西斯的化学辐射治疗的患者进行前性队列研究.
- 测量前庭眼反射增益 (VOR增益),宫前庭引起的肌源性潜能幅度 (cVEMP幅度) 和听力敏度.
- 治疗前后功能的比较,以及与西斯普拉丁剂量的相关性.
主要成果:
- 在cVEMP振幅显著下降 (p < 0.01) 和听力敏度恶化 (p < 0.01).
- 总体而言,VOR增益没有显著下降,但在接受更高剂量的西斯丁剂量 (> 200 mg/m2) 的患者中显著下降.
- 在调整年龄和辐射剂量后,VOR增长与增加的西斯普拉丁剂量呈反向关系.
结论:
- 基于西斯普拉丁的化学放射治疗导致VOR增益降低和潜在的前庭功能障碍.
- 建议在治疗前后进行前体和听觉测试,以早期检测耳毒性.
- 启动前庭物理治疗可以改善患者的生活质量.
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