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Updated: Sep 20, 2025

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在人类MAPT突变P301L和P301T中,有明显的丝折叠

Manuel Schweighauser1, Yang Shi1,2, Alexey G Murzin1

  • 1Medical Research Council (MRC) Laboratory of Molecular Biology, Cambridge, UK.

Nature structural & molecular biology
|May 29, 2025
PubMed
概括

基因 (MAPT) 的突变会导致前性痴呆和帕金森症 (FTDP-17). 冷EM揭示了与P301L和P301T突变相关的明显的丝结构,为疾病机制提供了洞察力.

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