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基于转录基因组的人类普遍衰老指数 (hUSI) 在各种条件下强有力的预测细胞衰老

Jing Wang¹, Xiaolan Zhou¹, Peng Yu^1,2

¹State Key Laboratory of Genetics and Development of Complex Phenotypes, National Clinical Research Center for Aging and Medicine, Huashan Hospital, Collaborative Innovation Center of Genetics and Development, Human Phenome Institute, Center for Evolutionary Biology, Shanghai Engineering Research Center of Industrial Microorganisms, School of Life Sciences, Fudan University, Shanghai, China.

|May 29, 2025

概括

一个新的人类普遍衰老指数 (hUSI) 准确地识别衰老细胞. 这种工具有助于衰老研究和临床实践,通过揭示不同细胞和COVID-19等疾病中的衰老.

科学领域:

细胞生物学细胞生物学
老年学是指老年学的学科.
生物技术是生物技术.

背景情况:

细胞衰老与衰老和疾病有关,但难以准确识别.
现有的方法使用有限的标记物或均的样本,阻碍了概括性.
衰老细胞的异质性对普遍检测提出了挑战.

研究的目的:

开发一种强大而准确的方法,在各种细胞类型和样本中评估细胞衰老.
创建人类普遍衰老指数 (hUSI) 以改进衰老检测.
应用hUSI来发现衰老调节剂和在疾病背景下分析衰老.

主要方法:

基于全面的转录组数据开发人类普遍衰老指数 (hUSI).
利用机器学习来识别细胞衰老的普遍特征.
应用hUSI来分析COVID-19和黑色素瘤患者样本中的衰老.

主要成果:

hUSI与衰老现象型和强大的衰老状态预测有很强的相关性.
发现了细胞衰老的潜在新型调节剂.
在COVID-19期间,在各种细胞类型中绘制衰老细胞积累的地图.
解码异质衰老状态,并确定黑色素瘤的预后相关途径.

结论:

人类普遍衰老指数 (hUSI) 为评估细胞衰老提供了一个准确而强大的方法.
hUSI有助于在不同的生物环境中描述衰老,包括衰老和疾病.
这种工具在衰老研究和临床实践中具有广泛的潜在应用,以了解衰老异质性.

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