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Updated: Feb 23, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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Published on: October 26, 2015

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发现了针对乳腺癌选择性向CDK2的新型纯素类似物:优化,合成,生物评估和对接研究

Mahesh Rupapara1,2, Nishith Teraiya3, Chetan Sangani4

  • 1Department of Cardiothoracic Surgery, Children's Hospital of Nanjing Medical University, Nanjing, 210008, People's Republic of China.

Molecular diversity
|May 29, 2025
PubMed
概括

新的精氨酸衍生物通过抑制CDK2表现出强大的抗癌活性,为乳腺癌治疗提供了一个有前途的策略. 化合物5e和5f对三阴性乳腺癌细胞系表现出显著的有效性.

关键词:
抑制了CDK2的发生.细胞毒性 细胞毒性停靠的对接方式纯氨酸核酸是一种纯氨酸核酸.

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