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神经元启发的铁电生物电子技术用于自适应生物接口
Fang Wang1,2, Lulu Wang3, Xule Zhu1
1State Key Laboratory of Biomedical Imaging Science and System, Center for Intelligent Biomedical Materials and Devices (IBMD), Shenzhen Institutes of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), Shenzhen, 518055, P. R. China.
Advanced materials (Deerfield Beach, Fla.)
|May 30, 2025
概括
创新的神经元启发的铁电生物电子 (FerroE) 提供了自适应的神经接口. 这些生物相容设备可以无线控制生理功能,并显示长期稳定性,为先进的大脑机器接口铺平了道路.
科学领域:
- 生物电子学 生物电子学
- 神经科学是一个神经科学.
- 材料科学 材料科学 材料科学
背景情况:
- 植入式生物电子对于神经科学和治疗神经系统疾病至关重要.
- 传统设备由于不相似的特性而难以与自适应神经接口进行斗争.
- 存在对具有神经元优先特征和行为的生物电子技术的需求.
研究的目的:
- 开发创新的神经元启发的铁电生物电子 (FerroE) 以改善神经接口.
- 将FerroE赋予神经元偏好的特性和神经元类似的行为.
- 在体内展示FerroE的自适应接口和功能能力.
主要方法:
- 使用聚多巴胺修饰的酸纳米颗粒,铁电共聚合物和微金字塔结构制造FerroE.
- 铁因其柔性,地形和光诱导的极化特性而进行表征.
- 在小鼠体内测试以评估神经接口,生理调节和稳定性.
主要成果:
- FerroE表现出神经元喜欢的灵活性和地形,以及与神经元相似的光诱导极化和信号生成.
- 实现了无线,非遗传和非接触心率和运动行为的调节.
- 前所未有的结构和功能稳定性,在植入后3个月后观察到可以忽略的免疫反应.
结论:
- 由神经元启发的FerroE提供了与神经系统的自适应接口.
- FerroE为下一代大脑机器接口和生物医学设备提供了一个有前途的平台.
- 这些生物灵感材料在组织工程和神经调节方面开辟了新的途径.
相关概念视频
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01:09Synaptic Signaling
Neurons communicate at synapses, or junctions, to excite or inhibit the activity of other neurons or target cells, such as muscles. Synapses may be chemical or electrical.
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
Most synapses are chemical, meaning an electrical impulse or action potential spurs the release of chemical messengers called neurotransmitters. The neuron sending the signal is called the presynaptic neuron, and the neuron receiving the signal is the postsynaptic neuron.
The presynaptic neuron fires an action potential that...
01:28Electrical Synapses
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01:12Mechanically-gated Ion Channels
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01:30Ligand-Gated Ion Channel Receptor: Gating Mechanism
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