在古代巨型昆虫的内生共生体中加速伪基化
Jinyeong Choi1, Pradeep Palanichamy1, Hirotaka Tanaka2,3
1Evolution, Cell Biology, and Symbiosis Unit, Okinawa Institute of Science and Technology Graduate University, Okinawa 904-0495, Japan.
Molecular biology and evolution
|May 30, 2025
概括
古代的共生生物,如细菌Walczuchella,可以迅速失去基因. 新的研究表明,Walczuchella的基因组高度降解,特别是在获得新的共生伙伴后.
科学领域:
- 微生物基因组学 微生物基因组学
- 进化生物学是进化的生物学.
- 共生研究是对共生的研究.
背景情况:
- 交生微生物由于环境和遗传压力而遭受基因损失.
- 微小的细菌基因组被认为是稳定的,但可以经历持续的伪基因化.
- 此前曾有报道称,巨型昆虫中的古代共生生物Walczuchella具有异常丰富的伪基因基因组.
研究的目的:
- 研究Walczuchella基因组中基因损失的程度和驱动因素.
- 为了确定古代共生体是否经历了快速基因损失的爆发.
- 评估共生体获取对基因组降解的影响.
主要方法:
- 从三种巨型昆虫属中生成六个完整的Walczuchella基因组.
- 对Walczuchella基因组进行比较基因组分析.
- 识别伪基因的基因和分析受影响的功能类别.
主要成果:
- 所有测序的Walczuchella基因组都高度降解.
- 与细胞外和能量代谢相关的基因显示出显著的伪基因化.
- 有证据表明,基因组降解加速,特别是在共生生物获得后.
结论:
- 具有小基因组的古代共生生物可以经历快速的基因损失.
- 丢失DNA复制和修复基因,加上共生体的获取,可能会加速Walczuchella基因组的退化.
- 选择压力和随机过程的变化可以推动微生物共生体中基因损失的爆发.
更多相关视频
07:28Methods for the Extraction of Endosymbionts from the Whitefly Bemisia tabaci
Published on: June 19, 2017
10.0K
09:44Identification of Critical Conditions for Immunostaining in the Pea Aphid Embryos: Increasing Tissue Permeability and Decreasing Background Staining
Published on: February 2, 2016
10.1K
相关概念视频
Diversity of Protists I
145
Excavata is a diverse group of protists that includes both chemoorganotrophic and phototrophic species, with some thriving in anaerobic environments. Among the key groups within Excavata are diplomonads and parabasalids, which are flagellated protists that lack mitochondria and chloroplasts. These microorganisms typically inhabit anoxic environments, such as the intestines of animals, where they exist either symbiotically or as parasites, relying on fermentation for energy production. Some...
145
Eukaryotic Evolution
36.9K
The endosymbiont theory is the most widely accepted theory of eukaryotic evolution; however, its progression is still somewhat debated. According to the nucleus-first hypothesis, the ancestral prokaryote first evolved a membrane to enclose DNA and form the nucleus. Conversely, the mitochondria-first hypothesis suggests that the nucleus was formed after endosymbiosis of mitochondria.
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
Contrary to the endosymbiont theory, the eukaryote-first hypothesis proposes that the simpler prokaryotic and...
36.9K
Exon Recombination
3.7K
The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes.
Exon shuffling follows “splice frame rules.” Each exon...
Exon shuffling follows “splice frame rules.” Each exon...
3.7K
Diversity of Protists II
154
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
154
Diversity of Protists III
142
Rhizaria are a diverse group of unicellular protists characterized by their threadlike cytoplasmic extensions known as pseudopodia. These structures aid in both locomotion and feeding, giving Rhizaria an amoeboid appearance. Their amoeboid morphology once led to taxonomic confusion, but molecular phylogenetics has clarified their evolutionary placement and emphasized their shared use of pseudopodia despite divergent lineages.This clade comprises diverse lineages such as Chlorarachniophyta,...
142
Genome Size and the Evolution of New Genes
8.4K
While every living organism has a genome of some kind (be it RNA, or DNA), there is considerable variation in the sizes of these blueprints. One major factor that impacts genome size is whether the organism is prokaryotic or eukaryotic. In prokaryotes, the genome contains little to no non-coding sequence, such that genes are tightly clustered in groups or operons sequentially along the chromosome. Conversely, the genes in eukaryotes are punctuated by long stretches of non-coding sequence.
8.4K
