相关实验视频
Updated: Sep 20, 2025
11:12
Controlling Parkinson's Disease With Adaptive Deep Brain Stimulation
Published on: July 16, 2014
22.6K
在深度大脑刺激后,刺激诱导的运动障碍的融合途径
Joshua K Wong1, Andreas Horn2,3, Erik H Middlebrooks4
1Norman Fixel Institute for Neurological Diseases, University of Florida, Gainesville, Florida, USA.
概括
在深度大脑刺激 (DBS) 过程中,刺激诱导的动力障碍 (SID) 与亚太拉莫-状纤维有关. 调节这些纤维与SID相关,这表明在帕金森病治疗中有共同的途径.
科学领域:
- 神经科学是一个神经科学.
- 神经外科 神经外科
- 运动障碍 运动障碍
背景情况:
- 刺激诱导的动力障碍 (SID) 来自深度大脑刺激 (DBS) 针对下丘脑核 (STN) 或内球 (GPi) 越来越多地被认为是潜在的治疗限制副作用.
- 尽管SID具有临床意义,但其确切的机制和解剖学的基础仍然不太清楚.
研究的目的:
- 调查刺激诱导的动力障碍 (SID) 的解剖基础,与下丘脑核 (STN) 和内球体 (GPi) 相关的深度大脑刺激 (DBS).
- 为了确定在DBS期间调节的特定纤维通道,与SID的发生相关.
主要方法:
- 在接受STN或GPi DBS的帕金森病患者中,对137个单极刺激观察结果的回顾性分析.
- 利用歧视性纤维通道分析和交叉验证技术来评估SID和调制纤维通道之间的关联.
主要成果:
- 发现SID与全球内体 (GPi) 队列中下层-层纤维的调节之间存在强烈的关联.
- 这种相关性通过交叉验证得到验证,并在独立的STN和GPi队列中成功预测了SID.
结论:
- 来自STN或GPi DBS的刺激诱导性运动障碍 (SID) 可能涉及与亚thalamo-pallidal连接相关的共同途径.
- 这些特定纤维的DBS调节与SID相关,这表明它们在一个更广泛的,尚未完全描述的功能障碍网络中的作用.
更多相关视频
14:14Targeting Neuronal Fiber Tracts for Deep Brain Stimulation Therapy Using Interactive, Patient-Specific Models
Published on: August 12, 2018
9.0K
09:46Analysis of Gene Expression Changes in the Rat Hippocampus After Deep Brain Stimulation of the Anterior Thalamic Nucleus
Published on: March 8, 2015
11.1K
相关概念视频
01:22Muscle Stimulation Frequency
2.7K
The contraction strength of muscles is regulated by motor neurons, which modulate the frequency of action potentials dispatched to the motor units based on the body's requirements. This process of varying the muscle stimulation frequency allows muscles to contract with a force that is precisely tailored to the needs of the moment, whether lifting a feather or a heavy box.
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
Wave summation
At low firing rates, motor neurons induce individual twitch contractions in muscle fibers. These twitches...
2.7K
01:11Direct Motor Pathways
2.5K
The direct motor pathways, also known as the pyramidal tracts, are a group of neural pathways that originate in the brain and descend through the spinal cord. They control the voluntary movement of the body. There are two major direct motor pathways: the corticospinal and the corticobulbar tracts.
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
The corticospinal tract is responsible for the voluntary movement of the limbs and trunk. It originates in the cerebral cortex of the brain and descends through the cerebrum's internal capsule and...
2.5K
01:20Motor Unit Stimulation
2.0K
When the neuron of a motor unit fires an action potential, it triggers a series of events, leading to a twitch contraction in the muscle fibers. The process of excitation-contraction coupling is crucial in relaying the action potential to the muscle fibers.
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
The latent period of contraction marks the onset of excitation-contraction coupling, when the action potential propagates across the sarcolemma, preparing the muscle fibers for contraction. As the fibers enter the contraction phase, the...
2.0K