ATRX ADD ,H2A,H3.

Shukun Yan1, Xiaoman Wang1, Kexue Ge1

  • 1Key Laboratory of Epigenetic Regulation and Intervention, Shanghai Institute of Biochemistry and Cell Biology, Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences; University of Chinese Academy of Sciences, Shanghai 200031, China.

概括

阿尔法沙拉西米亚/精神发育迟缓,X链蛋白 (ATRX) 通过其ADD域与基因素变体macroH2A相互作用. 这种相互作用是表观遗传调节和基因组稳定性的关键,揭示了对ATR-X综合征和癌症发病的新见解.

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