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相关概念视频

Cancer Therapies02:49

Cancer Therapies

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Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
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Cancer02:18

Cancer

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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Targeted Cancer Therapies02:57

Targeted Cancer Therapies

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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
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Cancer Vaccines01:30

Cancer Vaccines

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Treatment Resistant Cancers02:56

Treatment Resistant Cancers

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Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
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Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
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相关实验视频

Updated: Sep 20, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth

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为癌症研究带来价值.

Casey J Allen1, Horn M Danea2, Fabrice Smieliauskas3

  • 1Division of Surgical Oncology, Institute of Surgery, Allegheny Health Network, Pittsburgh, PA, United States.

Frontiers in oncology
|May 30, 2025
PubMed
概括

这项研究倡导在癌症临床试验中更广泛地定义价值,包括患者报告的结果和成本效益. 一个新的框架和视觉工具旨在改善共享决策和以患者为中心的癌症护理.

关键词:
临床试验是指临床试验中的临床试验.费用 费用 费用 费用 费用与目标一致的护理.质量质量质量质量质量质量.分享决策的决策.

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Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics
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科学领域:

  • 在瘤学瘤学.
  • 卫生经济学 卫生经济学
  • 临床试验设计 临床试验设计

背景情况:

  • 目前的癌症临床试验主要评估疗效和安全性.
  • 现有的框架往往忽视了关键的以患者为中心的方面,如生活质量,财务毒性和时间负担.
  • 成本效益通常不被纳入试验价值评估.

研究的目的:

  • 为癌症临床试验中定义和测量价值提出一个全面的框架.
  • 倡导将患者报告的结果 (PRO) 和成本分析与传统的终点结合起来.
  • 为增强基于价值的共享决策引入视觉工具.

主要方法:

  • 开发一个新的框架,整合瘤学结果,PRO和成本分析.
  • 关于价值评估的多维视觉工具 (例如雷达图表) 的建议.
  • 强调合作利益相关方的方法来定义价值指标.

主要成果:

  • 拟议的框架为评估癌症试验结果提供了更全面的方法.
  • 一个视觉工具可以帮助呈现复杂的价值数据,用于共享决策.
  • 标准化价值评估可以导致更公平,更有效的癌症护理.

结论:

  • 纳入更广泛的价值定义,包括PRO和成本效益,对于以患者为中心的癌症护理至关重要.
  • 对价值评估的协作,多维方法可以改善临床试验设计和患者的结果.
  • 在癌症研究中价值评估的标准化是提高护理公平性和有效性的关键目标.