扩散性异常性骨高静止症的全球患病率估计:系统性审查和元分析
Rui Weng1,2,3, Haiwei Guo2,3, Le Ma2,3
1School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong, China.
Frontiers in endocrinology
|May 30, 2025
概括
在全球范围内,扩散性异常性骨架强症 (DISH) 影响大约11.92%的普通人口和14.30%的临床患者. 这种情况在男性和50岁以上的个人中更为普遍.
科学领域:
- 类风湿病学 类风湿病学
- 流行病学 流行病学
- 整形外科 整形外科 整形外科
背景情况:
- 扩散性异常性骨高静止症 (DISH) 是一种全身性疾病,导致关节和带的骨化,在世界各地的不同人群中发现.
- 尽管在全球存在,但关于DISH的流行和发病率的综合数据仍然有限.
研究的目的:
- 进行系统性审查和元分析,以确定扩散性异常性骨高静止症 (DISH) 的全球流行率.
主要方法:
- 在2023年2月之前,使用Cochrane,MEDLINE和Embase数据库进行了基于人口和临床研究的系统审查.
- 数据提取的重点是跨大陆,性别,年龄组和种族的流行率,使用Joanna Briggs Institute 批判性评估工具进行质量评估.
- 采用随机效应模型来综合来自33项纳入研究的证据.
主要成果:
- 在一般人群中,DISH的总体估计患病率为11.92%,在临床患者中为14.30%.
- 流行率因地区而异,大洋洲在以人口为基础的研究中显示出最高的比例 (30.07%). 男性 (17.87%) 的患病率高于女性 (6.49%).
- 流行率也根据种族进行了分析,在以人口为基础的研究中,白人显示11.90%,黑人显示8.77%.
结论:
- 这一元分析提供了DISH全球流行情况的全面概述,突出了人口和人口统计学方面的显著差异.
- 这些发现证实,男性和50岁及以上的个人中DISH的患病率更高.
- 了解DISH的全球流行病学对于未来的研究和临床管理至关重要.
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