肠道微生物群和过敏性鼻炎之间的关联:系统性审查和元分析
Mengyao Li1, Qian Wang1,2, Ruikun Wang3
1Department of Otolaryngology-Head and Neck Surgery, Capital Institute of Pediatrics, Beijing, China.
PeerJ
|May 30, 2025
概括
这次元分析发现,过敏性鼻炎 (AR) 患者和健康对照人群之间肠道微生物群多样性或特定细菌类之间没有显著差异. 需要进一步的高质量研究来证实有关肠道微生物群和AR连接的这些发现.
科学领域:
- 微生物组研究 微生物组研究
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 过敏性鼻炎 (AR) 与肠道菌群有关,益生菌显示出治疗潜力.
- 人类对肠道微生物群和AR的观察研究显示了相互矛盾的结果.
- 需要清楚地了解肠道微生物群在AR中的作用.
研究的目的:
- 确定肠道微生物群和过敏性鼻炎之间的关系.
- 为AR和肠道微生物群相互作用提供临床参考.
- 通过元分析来综合现有证据.
主要方法:
- 在多个数据库 (PubMed,科学网等) 进行系统的文献搜索. 在2023年12月之前.
- 对10项涉及550名AR患者和385名健康个体的观察性研究的元分析.
- 使用R软件和纽卡斯尔-太华质量尺度评估alpha多样性 (Shannon,Simpson,Chao1) 和细菌族群的丰富性.
主要成果:
- 在AR患者和对照人群之间,阿尔法多样性指数 (Shannon,Simpson,Chao1) 没有统计学上显著的差异.
- 在主要细菌族群的丰富性中没有观察到显著的差异:Firmicutes, Bacteroidetes, Proteobacteria和Actinobacteria.
- 在大多数多样性和类分析中发现了高异质性 (I2 > 75%).
结论:
- 目前的证据不支持过敏性鼻炎和肠道微生物群失衡之间的联系.
- 为了得出最终的结论,需要更大的样本规模和更高质量的研究.
- 肠道微生物群在AR病变发生中的作用需要进一步研究.
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