乙墨醇诱导的有毒视神经病变的临床特征和视觉结果
Jenil Sheth1,2, Virender Sachdeva3, Ashima Goyal4
1Department of Pediatric, Strabismus and Neuro-ophthalmology, Shantilal Shanghvi Eye Institute, Wadala, Mumbai, Maharashtra, India.
Indian journal of ophthalmology
|May 30, 2025
概括
较高的乙胺醇剂量和年龄较大增加了有毒视神经病变 (ETON) 视力丧失的风险. 虽然在停止使用药物后,视力可能会部分恢复,但在长时间暴露于高剂量时,可能会出现严重的视力损伤.
科学领域:
- 眼科医生 眼科 眼科
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
背景情况:
- 乙墨托尔是一种一线抗结核药物.
- 乙醇诱导的有毒视神经病变 (ETON) 是一个重大问题.
- 了解ETON对视力的影响对于患者管理至关重要.
研究的目的:
- 为了描述ETON患者视力损失的严重程度.
- 为了研究与剂量相关的乙胺醇的不良影响.
- 为了确定ethambutol停止后的视觉结果.
主要方法:
- 印度南部 (2019-2021) 的前性观察研究.
- 包括107名成年患者在抗结核疗法中被诊断患有ETON.
- 分析了人口统计数据,视力丧失,以及停止服用乙醇后的结果.
主要成果:
- 分析了214只眼睛;平均年龄为51.1岁.
- 平均视力敏度在治疗后从1.2升至0.8 logMAR.
- 较高的乙胺醇剂量 (≥16 mg/kg) 与视力恶化相关.
结论:
- 高龄和高剂量的乙醇是视力丧失的危险因素.
- 长时间服用高剂量的乙墨醇可以导致严重的,可能部分可逆的视力损伤.
- 对于接受乙醇治疗的患者来说,仔细监测视力是必不可少的.
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