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自补充的新陈代谢增强的共生微球重塑肠骨平衡

Zhijie Chen¹, Hua Liu¹, Yi Chen¹

¹Department of Orthopaedics, Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases, Shanghai Institute of Traumatology and Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, 197 Ruijin 2nd Road, Shanghai, 200025, P. R. China.

Advanced materials (Deerfield Beach, Fla.)

|May 30, 2025

概括

这项研究引入了共生微球 (SMASMs),通过增强有益的肠道细菌和短链脂肪酸 (SCFA) 来恢复绝经后骨质疏松症的肠骨健康. 这些微球改善了骨密度和肠道屏障功能.

科学领域:

微生物学微生物学
生物材料科学生物材料科学
骨生物学骨生物学骨生物学

背景情况:

肠道微生物群失调和改变的短链脂肪酸 (SCFA) 代谢与绝经后骨质疏松症 (PMO) 有关.
现有的益生菌疗法往往忽视了SCFA代谢在肠骨平衡中的作用.

研究的目的:

开发和评估一种新的共生微观圈 (SMASM),用于在PMO中恢复肠骨平衡.
研究SMASM对肠道微生物群,SCFA生产和骨代谢的影响.

主要方法:

从PMO患者的便样本被测序.
合成微生物微球 (SMASMs) 是使用乳酸菌 (LGG) 和酸 (HA) 制造的.
在体外和体内 (切除卵子的小鼠) 的研究评估了SMASM的疗效,肠道屏障完整性,炎症和骨质损失.

主要成果:

在实验室中,SMASM证明了生物相容性,抗酸性和粘膜粘附性.
在小鼠中,口服SMASM改善了肠道屏障的完整性,减少了炎症,并抑制了骨质损失.
SMASMs增加了SCFA (黄油,异黄油,酸) 的产量,并支持微生物平衡.

结论:

通过肠-骨轴,SMASMs代表了通过肠-骨轴解决PMO中代谢障碍的有希望的策略.
氨酸作为一个关键的益生菌基质,增强LGG功能和SCFA生产.
这种方法为通过in situ发酵恢复肠骨平衡提供了新的见解.

关键词:

肠骨同质化肠骨同质化肠骨同质化氨酸原蛋白益生菌益生菌绝经后的骨质疏松症益生菌疗法是一种益生菌疗法.自己补充的微球.

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