高功率激光引发剂量依赖的急性损伤
Mantu Gupta1, Kavita Gupta1, Roman Shimonov1
1Department of Urology, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Journal of endourology
|May 30, 2025
概括
在石手术中使用的高功率激光会导致严重的损伤,这取决于使用的总能量,而不是激光类型. 老年患者和那些患有代谢综合征的人经历了更严重的伤害和更慢的恢复.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 生物医学工程 生物医学工程
背景情况:
- 高功率的激光器用于结石石的逆行性内外科手术 (RIRS).
- 以前的研究假设激光诱导损伤,但缺乏量化这种损伤的人类数据.
研究的目的:
- 在RIRS期间量化纤维激光 (TFL) 和Holmium:YAG (Ho:YAG) 激光器造成的损伤.
- 确定影响激光诱导损伤程度和恢复的因素.
主要方法:
- 接受结石RIRS治疗的患者被随机分配到TFL或Ho:YAG激光石.
- 尿液生物标志物 (损伤分子-1,NGAL,β2-微球蛋白) 在手术前,手术后1小时和手术后10天被测量.
- 为了进行比较,包括了没有使用激光的对照组.
主要成果:
- 无论是TFL和Ho:YAG激光器都导致了损伤生物标志物的显著,剂量依赖的升高.
- 损伤与使用的总激光能量,患者年龄和代谢综合征有关.
- 激光的类型 (TFL与Ho:YAG) 并没有显著影响受伤程度.
结论:
- 无论是TFL和Ho:YAG激光器,都会在RIRS期间以剂量依赖的方式诱导显著的损伤.
- 损伤会影响多个脏水平,并受到患者年龄和代谢综合征等因素的影响.
- 需要进一步的研究来探索减轻激光诱导损伤的方法.
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