结肠癌研究NCDB和SEER数据库的方法和生存比较
Metincan Erkaya1, Ekin Inal1, Cigdem Benlice2
1Department of Colorectal Surgery, Cleveland Clinic, Digestive Disease and Surgery Institute, Cleveland, Ohio, USA.
Journal of surgical oncology
|May 30, 2025
概括
这项研究比较了全国癌症数据库 (NCDB) 和监测,流行病学和最终结果 (SEER) 的结肠癌生存率. 这两个数据库都显示出一致的整体生存趋势,这对于研究人员选择结肠癌分析注册表至关重要.
科学领域:
- 在瘤学瘤学.
- 生物统计学 生物统计学
- 癌症研究 癌症研究
背景情况:
- 国家癌症数据库 (NCDB) 和监测,流行病学和最终结果 (SEER) 是结肠癌研究的关键资源,特别是整体生存率 (OS) 分析.
- 了解NCDB和SEER之间的人口结构,治疗和结果的差异对于准确的结肠癌生存率分析至关重要.
研究的目的:
- 系统地比较NCDB和SEER之间的患者特征,瘤结局和OS率,用于不同阶段和位置的结肠癌.
- 评估数据库结构和采样方法对结肠癌生存结果的影响.
主要方法:
- 分析了2004-2019年间为原发性结肠癌接受手术的患者 (I-IV阶段).
- 对NCDB和SEER之间的患者人口统计,瘤结果和OS率进行比较分析,按瘤位置和阶段分层.
- 评估数据库差异如何影响生存率的估计.
主要成果:
- 总共有777,827名患者被纳入 (NCDB:572,196;SEER:205,631).
- 人口和治疗差异被注意到,NCDB有更多的高加索患者,SEER有更多的亚洲患者. 在SEER中,细分切除更为常见.
- 在NCDB和SEER之间,整体存活率在很大程度上是可比的,在不同结肠位置和阶段观察到的微小变化.
结论:
- 在结肠癌生存趋势方面,NCDB和SEER表现出显著的一致性,尽管采样和随访的变化.
- 研究人员在为基于人口的生存分析选择注册表时,必须承认数据库特定的差异.
- 这项研究为选择合适的数据库提供了方法框架,澄清了先前结肠癌研究中的相互矛盾的发现.
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