阻塞性睡眠呼吸暂停,保持比率受损的螺旋计 (PRISm) 和全因死亡率:一个基于社区的前性研究
Yuhan Wang1, Mengcan Wang1, Beini Zhou1
1Department of Respiratory and Critical Care Medicine, Renmin Hospital of Wuhan University, Wuhan, China.
概括
阻塞性睡眠呼吸暂停 (OSA) 与保持比率受损螺旋计 (PRISm) 有关. 同病性OSA和PRISm显著增加死亡风险,强调需要进一步研究这一关联.
科学领域:
- 肺部医学 肺部医学
- 睡眠医学 睡眠医学
- 流行病学 流行病学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 和保持比率受损的螺旋计 (PRISm) 是常见的呼吸系统疾病.
- OSA和PRISM之间的关系,特别是在没有空气流阻塞的个体中,仍然没有得到充分的研究.
研究的目的:
- 调查可能的OSA (pOSA) 和PRISM之间的关联.
- 评估伴随性POSA和PRISM对所有死因死亡风险的影响.
主要方法:
- 对3408名20-79岁的成年人进行前性队列研究,没有空气流阻塞.
- 由症状定义的可能的OSA;通过螺旋测量定义的PRISM (FEV1<80%预测).
- 用多变量回归,考克斯回归和卡普兰-梅尔分析来评估关联和死亡风险.
主要成果:
- 在基线时,28.5%的人患有POSA,11.4%的人患有PRISM.
- 在pOSA和PRISM之间发现了一个独立的关联 (aOR=1.40).
- 与PISM单独治疗 (aHR = 1.78) 相比,并发性POSA和PRISm的死亡风险最高 (aHR = 2.34).
结论:
- 怀疑患有OSA的个人表现出PRISm的更高的患病率.
- 同病性OSA和PRISm与所有原因死亡率显著增加有关.
- 需要进一步的研究来探索OSA和PRISM之间的因果关系.
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