在间隔审查下估计最佳定制的主动监控策略
Muxuan Liang1, Yingqi Zhao2, Daniel W Lin3
1Department of Biostatistics, University of Florida, Gainesville, FL 32611, United States.
Biometrics
|May 30, 2025
概括
积极监测 (AS) 提供了癌症手术的替代方案,但涉及侵入性活检. 这项研究引入了一种针对AS策略的新方法,减少了活检负担并改善了患者的治疗结果.
科学领域:
- 生物统计学 生物统计学
- 医疗信息学 医疗信息学
- 癌症研究 癌症研究
背景情况:
- 主动监测 (AS) 是一种癌症管理策略,涉及重复活检.
- 活检是侵入性的,带有感染和出血等风险.
- 当前的AS协议缺乏个别定制,导致不必要的程序.
研究的目的:
- 开发一种用于估计定制的AS策略的方法.
- 为了考虑AS研究中的间隔审查和患者脱而出.
- 根据个体患者的风险和成本效益分析,优化AS强度.
主要方法:
- 使用非参数的基于内核的方法来估计真正阳性率 (TPR) 和真负率 (TNR).
- 开发了一个加权分类框架,以估计最佳定制的AS战略.
- 该方法包括成本效益的成本效益比率.
主要成果:
- 拟议的方法准确地估计TPR和TNR在存在间隔审查和脱学时.
- 估计了一个最佳的AS策略,平衡TPR和TNR.
- 该方法在模拟和前列腺癌研究中表现出优越性.
结论:
- 拟议的方法为个性化癌症监测提供了一个统计严格的方法.
- 这种技术可以减少AS的侵入性活检的负担.
- 它可以使更具成本效益和个性化的癌症护理决策.
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