一个生物混合纳米引擎驱动益生菌介导的癌症治疗
Bin Luo1,2, Yu Zhang1,2, Jiadai Yi1,2
1State Key Laboratory of Rare Earth Resources Utilization and Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin, 130022, P. R. China.
Small (Weinheim an der Bergstrasse, Germany)
|May 30, 2025
概括
具有Janus纳米结构的工程益生菌通过自我推进和调节瘤微环境 (TME) 来克服瘤障碍. 这增强了益生菌的运动性和抗癌疗效,改善了癌症治疗.
科学领域:
- 生物技术是生物技术.
- 纳米医学是一种纳米医学.
- 癌症治疗 癌症治疗
背景情况:
- 益生菌调节免疫力,分泌抗癌化合物.
- 临床使用受到益生菌运动性差和有害瘤微环境 (TME) 代谢物的限制.
- 乳杆菌reuteri (Lr) 具有抗癌潜力,但在TME中遭受不运动和反应性氧物种的影响.
研究的目的:
- 为增强益生菌运动性和TME调节设计一种生物混合纳米设备.
- 通过增强瘤透和生存能力来提高益生菌的抗癌疗效.
- 开发一种用于纳米发动机驱动的益生菌介导癌症治疗的多功能平台.
主要方法:
- 通过不对称地使用PEGylated Fe/Co/Cu/W纳米颗粒 (Fcw) 修改Lr表面,用Janus纳米结构设计了Lctobacillus reuteri (Lr).
- 利用Fcw的甲基酶类和S-酸 (GSNO) 降解活性来分解过氧化和GSNO,产生氧和氧化用于推进.
- 提高Fcw的谷氨过氧化酶类活性,以增强氧化应激并改善抗癌效应.
主要成果:
- 生物混合纳米设备成功地推动了工程Lr,克服了生物障碍并增加了瘤透.
- 过氧化和GSNO通过Fcw的分解增强了Lr运动性和存活率.
- 通过Fcw增强的氧化应激改善了工程益生菌的整体抗癌活性.
结论:
- 开发的纳米引擎策略显著增强了益生菌的运动性和TME调节.
- 这种方法提高了益生菌的生存能力和癌症治疗中的治疗效率.
- 纳米引擎平台为开发先进的益生菌媒介癌症疗法提供了一个有前途的战略.
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