lncRNA H19作为自身免疫的分子静剂:调节miRNA介导的基因调节和免疫细胞重编程
Thikra Majid Muhammed1, Mahmood Yaseen Mukhlif2, Ahmed Hossein3,4,5
1Biology Department, College of Education for Pure Sciences, University of Anbar, Baghdad, Ramadi, 31001, Iraq.
Naunyn-Schmiedeberg's archives of pharmacology
|May 30, 2025
概括
长非编码RNA H19 (lncRNA H19) 是免疫反应和自身免疫性疾病的关键调节者. 它的改变表达表明它有可能成为这些疾病的诊断生物标志物和治疗点.
科学领域:
- 免疫学 免疫学 免疫学
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 自身免疫性疾病是由遗传,环境和表观遗传因素的复杂相互作用引起的,导致对自身抗原的免疫反应.
- 长非编码RNAs (lncRNAs) 越来越多地被认为是它们在调节生物过程中的作用,包括免疫功能.
研究的目的:
- 审查 lncRNA H19 在自身免疫性疾病免疫病原发生中的多方面的作用.
- 探索lncRNA H19在治疗自身免疫性疾病方面的治疗潜力.
主要方法:
- 关于 lncRNA H19.9 的最新发现的文献综述.
- 在免疫细胞和炎症通路中分析lncRNA H19的调节机制.
- 检查lncRNA H19与信号级联 (例如NF-κB) 和microRNA网络的相互作用.
主要成果:
- lncRNA H19作为免疫细胞行为,炎症反应和表观遗传修饰的关键调节者.
- 它影响促炎和抗炎细胞因子的平衡,并控制T细胞分化,影响免疫耐受性.
- lncRNA H19的失调与自身免疫性疾病的进展和临床表现有关.
结论:
- lncRNA H19在免疫系统的调节中起着重要作用,并与自身免疫性疾病的发展有关.
- 改变的lncRNA H19表达呈现它作为一个有前途的诊断生物标志物和潜在的治疗目标对自身免疫性疾病.
相关概念视频
lncRNA - Long Non-coding RNAs
9.8K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
9.8K
lncRNA - Long Non-coding RNAs
3.5K
3.5K
MicroRNAs
3.8K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.8K
MicroRNAs
23.9K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
23.9K
Types of RNA
9.1K
Three main types of RNA are involved in protein synthesis: messenger RNA (mRNA), transfer RNA (tRNA), and ribosomal RNA (rRNA). These RNAs perform diverse functions and can be broadly classified as protein-coding or non-coding RNA. Non-coding RNAs play important roles in regulating gene expression in response to developmental and environmental changes. Non-coding RNAs in prokaryotes can be manipulated to develop more effective antibacterial drugs for human or animal use.
RNA Performs Diverse...
RNA Performs Diverse...
9.1K
Co-activators and Co-repressors
8.4K
Gene transcription is regulated by the synergistic action of several proteins that form a complex at a gene regulatory site. This is observed in eukaryotes, where the regulation of gene expression is a complex process. Regulatory proteins in eukaryotes can broadly be classified into two types – regulators that bind directly to specific DNA sequences and co-regulators that associate with regulatory proteins but cannot directly bind to the DNA. These co-regulators are further divided into...
8.4K


