相关实验视频
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Published on: December 31, 2013
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在实验诱导和使用依赖的可塑性后,对初级运动皮层的调节在年轻和老年人中
John Cirillo1,2,3, Carys R Ward4, Nicholas Gant4,5
1Department of Exercise Sciences, The University of Auckland, Auckland, New Zealand. john.cirillo@adelaide.edu.au.
Experimental brain research
|May 30, 2025
概括
年龄降低了运动皮层的可塑性,但心肺呼吸能力可能会支持它. 配对关联刺激 (PAS) 在年轻成年人中增强了兴奋能力,而技能获取没有显示年龄差异. 长间隔内皮抑制 (LICI) 在PAS后的年龄组之间存在差异.
科学领域:
- 神经科学是一个神经科学.
- 发动机控制器的控制器
- 衰老研究研究 衰老研究
背景情况:
- 运动功能至关重要的运动皮层 (M1) 可塑性可能随着年龄的增长而下降.
- 皮层内抑制对于M1可塑性至关重要.
- 身体活动可以增强M1的可塑性.
研究的目的:
- 为了研究伴侣关联刺激 (PAS) 和运动技能的获得后,M1刺激和抑制的年龄相关差异.
- 检查心肺健康在调节这些反应中的作用.
- 了解干预措施如何影响年轻和老年人的皮质运动刺激性和皮质内抑制 (SICI和LICI).
主要方法:
- 招募了31名老年人 (60-88岁) 和20名年轻人 (20-33岁) 成人.
- 使用跨磁刺激 (TMS) 来评估皮质运动兴奋能力,短间隔内皮质抑制 (SICI) 和长间隔内皮质抑制 (LICI).
- 干预包括配对关联刺激 (PAS) 和连续的视觉同度力任务,以获得运动技能.
主要成果:
- 在PAS后,皮质运动兴奋性在年轻人中增加,而不是老年人;技能获得没有显示年龄差异.
- 通过PAS诱导的兴奋度促进与心肺呼吸能力正相关.
- 在PAS之后,SICI下降,在技能获取后增加 (没有年龄差异).
- 在PAS后,LICI在年轻人中增加,在老年人中降低;在技能获取后没有变化.
结论:
- 干预措施通过差异调节M1抑制.
- 在PAS后观察到与年龄相关的LICI差异.
- 更高的心肺呼吸能力与PAS后更大的皮质运动兴奋度促进有关.
- 这些发现可以为减轻与年龄相关的认知和运动衰退的策略提供信息.
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