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新兴的趋势是,多种耐药生物在通风的新生儿中引起败血症
Sudesh Kumar1, Prajna Ray, Ranita Sahana
1Department of Paediatrics, MGM Medical College, Kishanganj, Bihar, India.
Annals of African medicine
|May 30, 2025
概括
多种耐药生物在新生儿重症监护室中构成重大威胁. 这项研究发现,这些耐药细菌,特别是格拉姆阴性菌株,在感染败血症的新生儿中存在很高的患病率.
科学领域:
- 新生儿科学 新生儿科学
- 传染性疾病 传染性疾病
- 微生物学 微生物学
背景情况:
- 抗生素和多药性耐药性 (MDR) 构成重大公共卫生风险.
- 在重症监护室 (ICU) 中,MDR生物是一个主要问题.
- 在新生儿重症监护室的新生儿特别容易感染感染.
研究的目的:
- 识别和确定MDR生物在败血症阳性通风新生儿中的流行率.
- 评估这些孤立的MDR生物体的抗生素耐药性模式.
- 评估MDR对新生儿败血症结局的影响.
主要方法:
- 在新生儿ICU中进行了一项观察性横截面研究.
- 招募了168名新生儿,收集了关于培养阳性和生物体识别的数据.
- 对孤立的MDR菌株分析了抗生素耐药性模式.
主要成果:
- 在168名通风新生儿中,79名 (47.02%) 观察到培养阳性.
- 53 (67.08%) 的孤立生物是MDR,其中格拉姆阴性菌株更为普遍 (56.6%).
- Pseudomonas aeruginosa 和凝血酶负型葡萄球菌 (CONS) 是最常见的MDR生物体. 针对常见的抗生素发现了高耐药率.
结论:
- 在EONS中,MDR生物体的流行率惊人高,特别是格拉姆阴性菌株.
- 存在MDR限制了最初的抗生素选择,可能会增加死亡率和发病率.
- 需要有效的策略来打击新生儿ICU中耐药生物体的传播.
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