在视觉皮层电路内,突触性和内在的恒常性可塑性的模块化安排
Wei Wen1, Adriana M Prada1, Gina G Turrigiano1
1Department of Biology, Brandeis University, Waltham, MA 02453.
概括
突触缩放和内在的恒常性可塑性 (IHP) 稳定神经网络. 这些机制可以独立地被招募来调节不同的网络活动特征,支持神经可塑性的模块化模型.
科学领域:
- 神经科学是一个神经科学.
- 计算神经科学是一种神经科学.
- 系统神经科学 系统神经科学
背景情况:
- 新皮质电路依赖于恒常性可塑性来维持稳定的网络活动.
- 突触缩放和内在的恒常性可塑性 (IHP) 是关键机制,但它们的招募和相互作用仍然不清楚.
研究的目的:
- 调查突触缩放和IHP是否在动物视觉皮层层2/3金字塔神经元中冗余或独立地起作用.
- 要确定这些恒温机制是按层次排列还是按模块排列.
主要方法:
- 在体外和体内利用药理学和遗传学干扰.
- 操纵神经元激增活动和NMDA受体 (NMDAR) 信号传递.
- 评估视觉体验的变化.
主要成果:
- 突触缩放和IHP,尽管重叠的信号通路,被独立招募.
- 尖端活动变化招募了突触缩放,而NMDAR信号变化招募了IHP.
- 改变视觉体验可以选择性地触发IHP,而不会影响突触缩放.
结论:
- 这些发现支持了恒常性可塑性的模块化模型.
- 突触缩放和IHP响应和稳定神经网络活动的不同方面.
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