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Updated: Sep 20, 2025

Detecting the Ligand-binding Domain Dimerization Activity of Estrogen Receptor Alpha Using the Mammalian Two-Hybrid Assay
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由雄激素受体交互激活域和小分子药物形成的共价附加物仍然是无序的

Jiaqi Zhu1, Paul Robustelli1

  • 1Department of Chemistry, Dartmouth College, Hanover, New Hampshire 03755, United States.

Journal of chemical information and modeling
|May 30, 2025
PubMed
概括

针对内在无序的蛋白质的小分子形成共价添加物,改变蛋白质结构. 分子动力学模拟显示,这些附加物稳定了崩的螺旋形状,有助于开发强大的抑制剂,用于诸如前列腺癌等疾病.

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