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转移性乳腺癌患者的肉类症:系统性审查和元分析

Min Kyeong Jang¹, Sungwon Park², Chang Park³

¹Mo-Im Kim Nursing Research Institute, Yonsei University College of Nursing, Seoul, South Korea.

Breast (Edinburgh, Scotland)

|May 30, 2025

概括

肉,或肌肉损失,影响超过40%的转移性乳腺癌患者. 虽然它没有直接影响生存率,但它的流行率强调了早期评估的必要性,以指导治疗策略.

科学领域:

在瘤学瘤学.
老年病的医生老年病的医生
代谢研究研究代谢研究

背景情况:

萨科佩尼亚与各种癌症的不良结果有关.
它在转移性乳腺癌 (MBC) 中的作用不太清楚.
这项研究解决了这一知识差距.

研究的目的:

为了确定MBC患者中肉类的患病率.
分析MBC中萨尔科佩尼亚的临床影响.
为了评估sarcopenia与治疗结果和存活率的关联.

主要方法:

在主要数据库 (CINAHL,Cochrane,Embase,Ovid MEDLINE) 进行系统文献审查,截至2024年10月.
对14项涉及1472名MBC参与者的研究进行了元分析.
计算平均骨肌肉指数 (SMI) 和评估生存相关性.

主要成果:

聚合的麻症患病率为41.6% (95% CI 35.4%-48.7%),具有显著的异质性.
平均SMI为41.01cm2/m2 (p < .001),根据SMI截止值有所不同.
没有发现软骨症和无进展或整体存活率 (HRs分别为1.17和0.99) 之间有统计学意义的关联.

结论:

在MBC中,sarcopenia的发病率很高,并且具有临床意义.
它对MBC存活率的直接影响目前尚不确定.
早期的萨尔科佩尼亚评估,考虑到分子亚型和治疗,对于患者的护理至关重要.

关键词:

乳腺新生体的形成.转移转移转移转移肌肉肌肉肌肉肌肉这是新质体新质体.审查审查审查审查萨尔科佩尼亚是什么意思萨尔科佩尼亚骨的骨架部分

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