儿科室内皮质关节阻塞和脑脊液蛋白质阻塞
Charles F Yates1, Michael J Colditz1, Liam Maclachlan2
1Dept. of Neurosurgery, Queensland Children's Hospital, Brisbane, Australia; Dept. of Neurosurgery, Royal Brisbane and Women's Hospital, Brisbane, Australia; School of Medicine, The University of Queensland, Brisbane, Australia.
概括
脑脊液蛋白 (CSFp) 水平升高预示着儿童的腹腔关 (VPS) 阻塞. 这一发现有助于管理分流并发症并改善患者的治疗结果.
科学领域:
- 神经外科 神经外科
- 儿科神经外科 儿科神经外科
- 生物标志物 生物标志物
背景情况:
- 腹腔关突变 (VPS) 对于治疗水头至关重要,但经常失败.
- 预测VPS阻塞是具有挑战性的,脑脊液蛋白 (CSFp) 水平是一个有争议的因素.
- 这项研究调查了CSFp在预测儿科患者VPS失败中的作用.
研究的目的:
- 为了确定脑脊液蛋白 (CSFp) 水平是否可以预测儿童的腹腔关节 (VPS) 阻塞.
- 评估CSFp度与早期 (<90天) 和晚期 (<1年) VPS阻塞的风险之间的关系.
- 提供证据证明CSFp在治疗儿科水脑病中的预后价值.
主要方法:
- 552个VPS手术在243名儿童 (2014-2019) 的回顾性审查.
- 分析大脑脊髓液蛋白 (CSFp) 水平,使用逻辑校正 (Log-CSFp),与VPS阻塞结果对比.
- 排除患有中枢神经系统感染的患者;多变量分析调整以考虑混因素.
主要成果:
- 10.5%的VPS套路在90天内受到阻碍,15.8%在一年内受到阻碍.
- 登录-CSFp是早期 (OR 1.40) 和晚期 (OR 1.37) VPS阻塞的重要预测因素.
- 发现老年患者的年龄对晚期VPS阻塞有保护作用 (OR 0.89).
结论:
- 大脑脊髓液蛋白 (CSFp) 水平具有预后价值,用于预测儿科患者的腹腔关节 (VPS) 阻塞.
- 测量CSFp可以为有关手术时间,患者随访和VPS并发症风险分层的决策提供信息.
- 这项研究有助于更好地管理孩子们的干线依赖性水头症.
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