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通过使用SmartReservoirs和形成水凝的微针,通过通过皮肤的途径控制释放阿米林

Abraham M Abraham¹, Amitha Simon¹, Qonita Kurnia Anjani¹

¹School of Pharmacy, Queen's University Belfast, Medical Biology Centre, 97 Lisburn Road, Belfast BT9 7BL, UK.

Biomaterials advances

|May 30, 2025

概括

智能储水池 (SRs) 提供了一种通过微针传递水友性药物的新方法. 与基于组织纸的SR相比,基于复印机纸的SR显示出更高的药物负载和增强的阿米氨酸化物通过皮肤输送.

科学领域:

药物交付和制药技术药物交付和制药技术
材料科学在医学中的科学.
生物材料工程生物材料工程

背景情况:

智能储水池 (SRs) 是用于凝形成微针 (HF-MN) 的纤维素基矩阵.
SRs可以提高难溶性药物的溶性,并修改水友性药物的特性,以控制释放.
通过透皮输送使用SRs用于水友药物,特别是阿米二化物 (AMT),此前还没有研究过.

研究的目的:

探索用智能储水器 (SRs) 集成与凝形成微针 (HF-MNs) 的水友性阿米氨酸化物 (AMT) 通过皮肤传递.
研究不同纤维素基矩阵 (纸张与复印机纸) 对药物加载和释放概况的影响.
以其物理化学性质和透皮透效率来表征制造的HF-MN和SR.

主要方法:

使用组织纸 (SR-T) 和复印机纸 (SR-P) 制造HF-MN和两种类型的AMT装载SR.
综合性表征包括形态,机械和物理化学特性,药物-纤维素相互作用,药物分发,载荷能力和透皮透.
进行了体外皮肤沉积和透研究,以评估药物递送效率.

主要成果:

活性药物成分 (API) 在SR-T和SR-P矩阵中保持完整.
基于复印机纸的SRs (SR-P) 呈现出明显更高的药物负载 (约. 8 mg/cm2) 和增强释放与基于组织纸的SR相比 (SR-T,大约. 4 毫克/厘米2).
与HF-MNs一起的SR-P实现了更高的皮肤沉积 (约. 128μg) 和透 (>500μg,~9%的输出) 与SR-T与HF-MNs (约. 75微克沉积,<150微克透,~5%的输出).

结论:

智能储是有效的药物储,用于水友性药物,当纳入HF-MN时.
选择纤维素基质显著影响药物负载和通过皮肤递送效率.
基于复印机纸张的SR显示出增强皮传递像阿米胺化等水友性药物的承诺.

关键词:

阿米特里普提林化.药物储备库是药物储备库.用纸制成的药物储存器是用纸制成的水友性药物是一种水友性药物.微针是一种微针.智能储水池是一种智能储水池.通过皮肤传递药物.

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