对子宫内膜异位症患者的卵细胞冷保存:我们现在的情况是什么? 一个系统的审查
Pierpaolo Nicolì1, Paola Viganò2, Gabriele Saccone3
1Unit of Obstetrics and Gynaecology, Department of Interdisciplinary Medicine, University of Bari 'Aldo Moro', Policlinico of Bari, Bari, Italy.
Reproductive biomedicine online
|May 30, 2025
概括
患有子宫内膜异位症的妇女的卵细胞冷保存显示,随着年龄的增加和之前的手术,卵子产量减少. 需要更多的数据来证实对子宫内膜异位症患者的生育保护的有效性.
科学领域:
- 生殖医学 生殖医学
- 妇科 妇科医生 妇科
- 在瘤学瘤学.
背景情况:
- 由于研究有限,目前对子宫内膜异位症患者卵细胞冷保存的建议尚不清楚.
- 在这个人口群体中评估生育保护的有效性至关重要.
研究的目的:
- 审查关于卵子冷保存和体外受精 (IVF) 在子宫内膜异位症患者的现有数据.
- 分析患者特征如何影响这些结果.
主要方法:
- 通过电子数据库搜索识别的10项观察性研究的系统审查.
- 由于研究异质性,提取的数据进行描述性分析.
- 在PROSPERO注册的协议 (CRD42023486774).
主要成果:
- 卵细胞产量随着年龄的增加而降低,在冷保存和经过子宫内膜异位症手术的历史中.
- 卵细胞产量没有受到子宫内膜异位症类型,横向性或子宫内膜瘤大小的显著影响.
- 转基因II期卵细胞产量遵循了类似的趋势;成熟率不受之前手术的影响.
结论:
- 关于使用冷保存卵子细胞的有限后续数据阻碍了预防性生育保护有效性的确认.
- 需要进行进一步的研究,并进行适当的随访,以建立关于卵细胞冷保存对子宫内膜异位症妇女有效性的科学确定性.
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