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双相情感障碍和一级亲属中的视网膜质细胞复合体稀薄:光学连贯断层扫描的证据

Nesrin Buyuktortop Gokcinar¹, Sadiye Visal Buturak², Ali Solmaz¹

¹Department of Ophthalmology, Faculty of Medicine, Kırıkkale University, Kırıkkale, Turkey.

Psychiatry research

|May 30, 2025

概括

在双相情感障碍 (BD) 患者和他们的亲属中发现了视网膜中减少的质细胞复合体 (GCC) 厚度,这表明BD的潜在遗传标志物.

科学领域:

神经科学是一个神经科学.
眼科医生眼科眼科
精神病学是一个精神病学.

背景情况:

双极性障碍 (BD) 是一种复杂的精神疾病,具有重要的遗传成分.
确定BD可靠的内分类型对于理解其病理生理学和开发向治疗至关重要.

研究的目的:

用光学连贯断层扫描 (OCT) 调查双相情感障碍 (BD) 患者,他们的未受影响亲属和健康对照的视网膜结构差异.
为了确定观察到的视网膜变化是否可以作为BD的内类型标记物.

主要方法:

一项涉及50名BD患者,40名未受影响的一级亲属和50名健康对照者的横截面研究.
光学连贯断层扫描 (OCT) 用于测量视网膜神经纤维层 (RNFL) 和状细胞复合体 (GCC) 厚度.
进行了统计分析 (ANOVA,Kruskal-Wallis,ANCOVA) 来比较群体,并根据年龄和性别进行调整.

主要成果:

与对照组相比,患有BD的患者在两只眼睛中显著减少了GCC厚度 (p < 0.01).
没有受影响的亲属也表现出较低的GCC值,表明潜在的遗传特征.
在各组中,RNFL的厚度通常是相似的,在使用者中有一个显著的例外.

结论:

在BD患者及其亲属中减少的GCC厚度表明了基因介导的脆弱性,并支持其作为双相情感障碍的内分类型的作用.
使用OCT视网膜成像提供了一种非侵入性方法来识别与BD相关的神经生物学变化.
这种方法可能有助于早期检测有双相情感障碍风险的个体.

关键词:

双极性障碍是一种双极性障碍.末型是一种内类型.团结细胞复合体团结细胞复合体遗传风险遗传风险遗传风险横向性横向性横向性光学连贯性断层扫描仪视网膜神经纤维层是一种神经纤维层.

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