全基因组关联研究揭示了康沃尔郡白人的翅膀骨强度的遗传机制
Longyu Zhuang1, Yuanhang Shi1, Xuefeng Shi1
1National Engineering Laboratory for Animal Breeding and MOA Key Laboratory of Animal Genetics and Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China; State Key Laboratory of Animal Biotech Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China; Key Laboratory of Animal Genetics, Breeding and Reproduction (livestock), Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, 100193, China.
Poultry science
|May 30, 2025
概括
由于产品质量受到影响的高骨折率,研究了肉翅膀骨强度. 全基因组关联研究确定了潜在改善骨完整性和肉福利的遗传位置和途径.
科学领域:
- 动物科学动物科学
- 遗传学 遗传学是一种遗传学.
- 养家禽生产 养家禽生产
背景情况:
- brojiler翅膀肉是有价值的,但高频率的翅膀骨变形和骨折降低了产品质量和经济效益.
- 了解翅膀骨强度的遗传基础对于改善肉生产和动物福利至关重要.
研究的目的:
- 为了确定与肉翅膀骨强度和性相关的遗传位置.
- 分析翅膀骨特征,生长和料转换率之间的相关性.
- 为基因选择提供基础,以提高肉骨质量.
主要方法:
- 一项全基因组关联研究 (GWAS) 在436只康沃尔郡白色身上进行,使用39000个SNP的定制 brojler微阵列.
- 测量包括肘部,半径,腰部和部的重量,长度,宽度,强度和性,以及生长和乳腺肌肉特征.
- 使用相关性分析和线性混合模型来分析遗传参数和SNP关联.
主要成果:
- 翅膀骨硬度显示出很高的变化 (CV>20%),骨硬度为34.45%.
- 翼骨特征与生长和骨特征正相关 (r=0.8),与料转换率负相关.
- GWAS确定了27个显著的SNP,其中最低的P值为2.263 × 10−7,以及八个与骨相关的基因,这些基因被丰富在关氨酸核酸交换因子活动途径中.
结论:
- 翅膀骨特征具有较低的遗传性,膀臂骨强度是最高的 (0.27).
- 确定了基因位置和通路,为改善肉骨强度提供了目标.
- 这项研究支持通过基因改进提高肉产品质量和动物福利.
相关概念视频
01:11Genome-wide Association Studies-GWAS
14.4K
Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
GWAS does not require the identification of the target gene involved in...
GWAS does not require the identification of the target gene involved in...
14.4K
02:32Position-effect Variegation
6.6K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
6.6K
02:54Canonical Wnt Signaling Pathway
9.0K
The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
9.0K
02:41Lethal Alleles
15.7K
Agouti: A Lethal Allele
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
Lucien Cuénot discovered lethal alleles in 1905 while studying the inheritance of coat color in mice. The agouti gene is responsible for the color of the coat in mice. This gene codes for an agouti-signaling protein, which is responsible for melanin distribution in mammals. The wild-type allele gives rise to gray-brown coat color in mice, while the mutant allele gives rise to yellow coat color. In addition to coat color, the agouti gene is associated with the yellow...
15.7K
01:43Incomplete Dominance
25.8K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
25.8K
00:49Complementation Tests
5.3K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
5.3K