超氧化物通过调节肠道菌群来改善肠道粘膜免疫力,防止泽拉伦诱导的肠道屏障损伤
Tianyu Han1, Yan Jiang1, Zhijun Liu1
1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China; Country Heilongjiang Provincial Key Laboratory of Pathogenic Mechanism for Animal Disease and Comparative Medicine, Harbin 150030, China; Institute of Chinese Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Veterinary immunology and immunopathology
|May 30, 2025
概括
超酸 (HYP) 通过恢复肠道屏障和免疫功能来保护小猪免受泽拉伦 (ZEA) 菌毒素的损害. 这项研究表明,HYP可减轻ZEA诱导的肠损伤和铁亡,为抵御菌毒素暴露提供了潜在的策略.
科学领域:
- 毒理学 毒理学 毒理学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
- 微生物学 微生物学
背景情况:
- 泽拉伦 (ZEA) 是一种已知会引起免疫毒性和肠道损伤的真菌毒素.
- 超氧化物 (HYP) 是一种天然的黄醇,具有多种药理学效应.
- 需要阐明HYP对ZEA诱导的肠道问题的保护机制.
研究的目的:
- 研究HYP在减轻ZEA诱导的肠道免疫抑制和小猪损伤方面的疗效.
- 探索HYP对ZEA毒性的保护作用的潜在机制.
主要方法:
- 猪仔皮质的组织学和超结构分析.
- 16S rRNA测序用于肠道微生物群的分析.
- qRT-PCR和ELISA用于评估肠道屏障功能,免疫反应和ZEA含量.
- 西部涂抹和qRT-PCR用于评估与铁死相关的指标.
主要成果:
- HYP显著减轻了ZEA诱导的猪内皮的组织学和超结构性损伤.
- HYP恢复了肠道菌群的丰富性和多样性,并增强了肠道屏障功能 (化学,物理,免疫).
- HYP减少了ZEA的积累,抑制了炎症性细胞因子的释放,并缓解了ZEA诱导的肠道铁.
结论:
- 超氧化物有效地保护小猪免受zearalenone诱导的肠损伤和免疫抑制.
- HYP通过恢复肠道屏障完整性,调节肠道微生物群,并抑制铁亡作用.
- HYP 提出了一个有前途的治疗策略,以减轻泽拉伦暴露的不良影响.
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