在真实患者解剖学中模拟提示性马 (PG) 发射,检测和成像,使用一种新的康普顿摄像头用于质子疗法中剂量验证
V R Sharma1, Z Jiang2, S Mossahebi3
1Department of Radiation Oncology, School of Medicine, University of Maryland, Baltimore, MD 21201, United States of America.
Physics in medicine and biology
|May 30, 2025
概括
快速马 (PG) 成像为质子疗法剂量验证提供了潜在的可能性. 一个新的蒙特卡罗模拟工具,PJ-MC,模拟了PG成像过程的完整性,提高了准确性,并优化了这种技术的临床用途.
科学领域:
- 医学物理 医学物理
- 核成像技术 核成像技术
- 辐射瘤学 辐射瘤学
背景情况:
- 快速马 (PG) 成像是实时验证质子剂量的有希望的方法.
- 目前在模拟整个PG成像链中存在患者解剖学的局限性.
- 需要有效的工具来评估和优化用于质子疗法的PG成像.
研究的目的:
- 开发一套蒙特卡罗模拟包 (PJ-MC) 用于患者解剖学的完整PG成像过程.
- 调查PG排放,检测和图像重建以验证剂量.
- 评估患者解剖学对PG图像准确性的影响.
主要方法:
- 使用Geant4和DCMTK开发了POLARIS J蒙特卡洛 (PJ-MC) 软件包.
- 在病人的沙发下模拟了一个两级POLARIS-J3康普顿摄像头.
- 建模了质子束,并将CT数据转换为voxelized几何形状.
- 使用内核权重反向投影重建PG图像.
主要成果:
- 在玛能量分布中,核反应 (O,C,N,Ca) 的清晰排放线被确定.
- 质子诱导的反应明显比中子诱导的反应更为主导.
- 与Dmax相比,PG范围验证在Dmax的80%或50%时更稳定.
- 发现患者解剖学会影响PG图像中的热点位置,影响布拉格峰位定位.
结论:
- PJ-MC模拟包为患者解剖学中的PG成像提供了宝贵的见解.
- 该工具可用于评估和优化PG成像,以提高质子疗法的精度.
- 该研究强调了考虑患者特异性解剖学的重要性,以准确的基于PG的剂量验证.
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