使用实验和模拟涂层技术探索涂层设计间距
Peter Böhling1, Johan Remmelgas1, Daniel To2
1Research Center Pharmaceutical Engineering GmbH, Graz, Austria.
International journal of pharmaceutics
|May 30, 2025
概括
计算流体动力学-离散元件方法 (CFD-DEM) 模拟准确建模的平板电脑涂层过程. 这种数字方法通过分析空气流对平板电脑移动和质量分布的影响来优化涂层均性和干燥效率.
科学领域:
- 化学工程是化学工程的重要组成部分.
- 制药科学 制药科学
- 计算机建模 计算建模
背景情况:
- 平板电脑涂层对于药物输送和稳定性至关重要.
- 优化涂层过程需要理解复杂的多相相互作用.
- 计算流体动力学离散元件方法 (CFD-DEM) 提供了一个强大的模拟工具.
研究的目的:
- 为了提高对实验室规模的平板电脑涂层工艺的理解.
- 使用CFD-DEM模拟来建模动量,热量和质量转移.
- 为了验证模拟结果与实验数据对比.
主要方法:
- 从实验设计空间中选择了八个过程点.
- 在使用CFD-DEM的模拟中进行.
- 分析了平板运动,涂层质量分布,温度和溶剂蒸发.
主要成果:
- 干燥空气流速显著影响了药片的移动和涂层的均性.
- 模拟显示变化系数的线性衰变,与实验发现相匹配.
- 预测的温度与实验值非常相匹配,在更高的温度下有轻微的过度预测.
结论:
- CFD-DEM模拟有效地将平板电脑涂层实验数字化复制.
- 这些模型提供了通过数字探索优化涂层过程的见解.
- 数字模拟有助于更好地理解空气流动动力学和干燥参数.
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