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高硫化玉米粉可以增强粘膜粘合和透

Zahra Davoudi¹, Gergely Kali², Doris Braun²

¹Department of Pharmaceutical Technology, University of Innsbruck, Institute of Pharmacy, Center for Chemistry and Biomedicine, Innrain 80-82, 6020 Innsbruck, Austria; Department of Food Science and Technology, Faculty of Agriculture, Tarbiat Modares University, Tehran, Iran.

International journal of pharmaceutics

|May 30, 2025

概括

高硫化玉米粉通过改善粘膜粘合和透来增强药物输送. 这种改性粉不表现出细胞毒性,使其成为粘膜应用的有希望的辅助剂.

科学领域:

材料科学材料科学材料科学
制药科学制药科学
生物技术是生物技术.

背景情况:

开发新型辅助剂对于有效的粘膜药物输送至关重要.
玉米粉是一种丰富且生物相容的多糖.
硫化可以修改粉的特性,以提高功能.

研究的目的:

为了合成和表征高硫化玉米粉.
评估其粘粘性和透性增强特性.
评估其作为粘膜药物递送的辅助剂的潜力.

主要方法:

使用 pentasulfide 进行原生玉米粉的化学硫化.
使用埃尔曼测试,1H NMR,FTIR和DSC进行表征.
通过resazurin可行性测定进行细胞毒性评估.
评估胀,粘度,粘膜粘合 (风湿学,拉伸性测试) 和透 (使用化).

主要成果:

硫化粉 (1658 μmol/g 硫醇组) 在0.2 mg/ml的剂量下没有表现出细胞毒性.
观察到动态粘度增加了3.5倍,粘膜粘合力提高了91.1倍.
拉伸测试显示,脱离力增加了4.3倍.
通过大鼠肠道粘膜证明了化的透增强的2倍增加.

结论:

高硫化玉米粉具有显著的粘膜粘合和透增强能力.
改性粉显示出良好的安全性.
它代表了一种有前途的辅助剂,用于推进粘膜药物递送系统.

关键词:

粘膜凝聚力粘膜凝聚力药物通过粘膜输送.增强透性的增强剂化聚合物化聚合物化粉的化粉.这种类型的基因组是 thiomers.

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