相关实验视频

Updated: Jun 14, 2025

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Induction of Ocular Surface Inflammation and Collection of Involved Tissues

Published on: August 4, 2022

用于治疗眼部炎症的粘膜粘合性状眼滴

Yuting Zheng¹, Yimin Gu¹, Yavuz Oz¹

¹Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA, 90095, United States.

Acta biomaterialia

|May 30, 2025

概括

新的粘粘性菌根眼滴装载着洛特普雷德诺埃塔博纳酸 (LE) 显著改善了眼部药物输送. 这些酸功能化聚合物微粒 (PBA-MCs) 的每日单剂量与需要四剂量的商业眼药的疗效相匹配,减少了眼部炎症.

科学领域:

眼科医生眼科眼科
材料科学材料科学材料科学
纳米技术纳米技术

背景情况:

眼部药物输送因生理障碍而面临挑战,导致低生物可用性和频繁的剂量治疗,如 loteprednol etabonate (LE) 眼滴.
商业眼科悬浮剂通常需要每天多次应用以维持治疗药物水平,影响患者的服药和治疗疗效.

研究的目的:

开发和评估一种新的粘粘性菌根药物递送系统,以提高 loteprednol etabonate (LE) 的眼部生物可用性和角膜保留.
在与商业眼药相比,对角膜炎症的小鼠模型中研究 phenylboronic 酸功能化聚合物微粒 (PBA-MCs) 的疗效.

主要方法:

合成了PBA功能化的聚 (乙烯基醇) -b-聚 (N-(2-基) 甲基胺-甲酸盐) (PBA-PEG-b-p(HPMA-Lacm)) 以创建聚合物微粒 (MCs).
在12天内持续释放LE的配方菌根眼滴.
评估了粘膜粘附,角膜保留,生物相容性,眼睛安全性和治疗疗效 in vitro,ex vivo 和 in vivo 的小鼠模型.

主要成果:

该PBA-MC配方表明持续的LE释放,增强的粘膜粘合和长时间的角膜保留.
在体内研究表明,每天服用一次带有LE的PBA-MC眼液显著减少小鼠的角膜炎症,不透明度和免疫细胞透.
装有LE的PBA-MC眼药剂的疗效与每天四次使用的商业LE眼药剂相当.

结论:

工程化PBA功能化的小眼滴代表了改善眼部药物输送和治疗眼部炎症的有希望的平台.
这种粘膜粘合系统增强了药物的生物可用性和保留性,可能减少剂量频率并改善患者对眼部炎症状况的治疗结果.

关键词:

抗炎药物抗炎药物抗炎药物眼滴眼滴眼滴眼滴状细胞药物输送.粘膜凝聚力粘膜凝聚力眼睛的炎症眼睛的炎症

更多相关视频

Conjunctival Commensal Isolation and Identification in Mice

Conjunctival Commensal Isolation and Identification in Mice

Published on: May 1, 2021

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Intense Pulsed Light for the Treatment of Dry Eye Owing to Meibomian Gland Dysfunction

Published on: April 1, 2019

相关概念视频

Open Angle Glaucoma: Treatment

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

Angle Closure Glaucoma: Treatment

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...