瘤微环境中的乳糖化和免疫疗法耐药性:新的机制和挑战
Wenlong Zhu1, Chang Fan1, Yizhuo Hou1
1Center for Translational Medicine, Naval Medical University, Shanghai, 200433, China.
Cancer letters
|May 30, 2025
概括
乳化是一种后翻译性修改,通过改变基因转录来促进瘤的进展和免疫治疗抵抗力. 向乳化提供了一种提高癌症治疗疗效的潜在策略.
科学领域:
- 在瘤学瘤学.
- 生物化学 生物化学
- 免疫学 免疫学 免疫学
背景情况:
- 瘤微环境 (TME) 是一个复杂的系统,通常以缺氧为特征.
- 作为华堡效应的产物,乳酸盐越来越多地被认为是超越新陈代谢的作用,作为乳酸化基质.
- 翻译后修饰 (PTMs),包括乳化,显著影响癌细胞信号传递,新陈代谢和瘤免疫抑制微环境 (TIME).
研究的目的:
- 审查乳酸化促进瘤进展的新型机制.
- 阐明乳化对瘤免疫抵抗的影响.
- 提出治疗策略来逆转乳糖化以增强瘤免疫疗法.
主要方法:
- 对癌症中乳化现有文献的综述.
- 分析基因转录和瘤促进中的基因母乳化作用.
- 探索用于识别乳化基质的多奥米克技术的进步.
主要成果:
- 基因激素乳化直接刺激基因转录,促进瘤生长.
- 乳化在塑造时间和加剧瘤免疫疗法耐药性方面发挥着至关重要的作用.
- 向乳化部位可能会降低基因素乳化,并减轻对免疫抵抗的影响.
结论:
- 乳化是驱动瘤进展和免疫规避的关键机制.
- 了解乳化作用对于开发有效的癌症疗法至关重要.
- 逆向乳化对结合疗法来说是有前途的,以克服瘤免疫抵抗.
更多相关视频
07:55Flow Cytometry-Based Isolation and Therapeutic Evaluation of Tumor-Infiltrating Lymphocytes in a Mouse Model of Pancreatic Cancer
Published on: January 17, 2025
684
09:15Experimental Melanoma Immunotherapy Model Using Tumor Vaccination with a Hematopoietic Cytokine
Published on: February 24, 2023
3.4K
相关概念视频
02:17The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
01:27Tumor Immunotherapy
493
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
493
02:56Treatment Resistant Cancers
3.3K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.3K