肠保持性输送系统用于改善疾病治疗
Xin Wu1, Wantao Wu1, Jutaek Nam2
1State Key Laboratory of Natural Medicines, China Pharmaceutical University, No. 639 Longmian Dadao, Nanjing 211198, China; Department of Pharmaceutics, China Pharmaceutical University, Nanjing 21009, China.
概括
肠保持药物递送系统 (DDS) 通过延长胃肠道停留时间来增强口服药物的疗效. 本综述探讨了改善DDS保留的工程策略及其对肠道免疫力的影响.
科学领域:
- 生物医学工程 生物医学工程
- 药品制造 药品制造 药品制造
- 胃肠病学 胃肠病学
背景情况:
- 口服药物递送系统 (DDS) 提供患者的服药性,但在胃过境时面临挑战.
- 延长DDS在胃肠道中的停留时间对于有针对性的输送和治疗疗效至关重要.
- 敌对的胃环境限制了敏感药物的保留,需要先进的输送策略.
研究的目的:
- 审查延长口服DDSs的肠道保留的工程策略.
- 讨论肠道运输时间的机制和影响因素.
- 通过长时间的DDS保留来探索肠道环境和全身免疫的调节.
主要方法:
- 关于DDS工程用于肠道保留的最新进展的文献综述.
- 分析纳米,微型和宏观规模的工程策略.
- 关于肠道保留机制的理论和证据的讨论.
主要成果:
- 不同规模的各种工程策略可以延长口服DDS的肠道保留时间.
- 了解肠道传输时间及其影响因素是DDS设计的关键.
- 长时间的DDS保留提供了调节粘膜免疫和肠道微生物群的潜力.
结论:
- 肠保持性DDS对口服药物传递敏感药物充满希望.
- 对保留机制的进一步研究可以优化DDS性能.
- 通过DDS调节肠道环境为肠道健康和免疫提供了治疗机会.
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