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Updated: Sep 19, 2025

Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
在用 omalizumab 治疗后引入过敏性食物
Jennifer Dantzer1, Yamini Virkud2, Julie Wang3
1Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Md.
大多数参与者在接受奥马利祖马布治疗后成功引入过敏性食物,与花生和树核相比,牛奶,蛋和小麦的成功率更高. 然而,出现了不良反应,一些参与者重新开始避免过敏原.
科学领域:
- 过敏和免疫学 过敏和免疫学
- 临床治疗学 临床治疗学
- 食品科学 食品科学 食品科学
背景情况:
- 奥马利祖马布治疗增加了对过敏性食物的反应值.
- 关于奥马利祖马布有可能促进对过敏原食物的引入饮食的可能性的数据有限.
研究的目的:
- 为了调查在停止奥马利祖马布治疗后将过敏性食物引入饮食.
主要方法:
- 来自OUtMATCH试验的60名参与者进入了24周的延长期,随后进入了第三阶段,该阶段涉及零售过敏性食品的饮食消费 (DC),救援口服免疫疗法或避免.
- DC成功被定义为每天至少消费300毫克的食物蛋白质12个月.
主要成果:
- 82%的参与者最初计划使用DC,牛奶,蛋和小麦的成功率 (61%-70%) 比花生和树坚果 (38%-56%) 高.
- 消费总体上随着时间的推移而下降,除了小麦,牛奶和蛋消费的变化.
- 更高的选挑战门预测了DC的成功. 这些不良事件包括过敏反应和eosinophilic食道炎.
结论:
- 大多数参与者可以在奥马利祖马布治疗后以饮食形式引入过敏性食物.
- 观察到不良反应,大量参与者恢复了对过敏原的避免.
- 这项研究是第一个在奥马利祖马布后对零售食品的引入进行检查的研究,强调了潜在的好处和风险.
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