解锁脂肪因子:肥胖如何影响结直肠癌的存活率 - 一个全面的元分析
Chun Gao1, Min Chen1, Yi Xin Tong1
1Department of Gastrointestinal Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People's Republic of China.
Clinical nutrition ESPEN
|May 30, 2025
概括
较高的皮下脂肪与结直肠癌 (CRC) 患者的更好的生存率有关,而内脏脂肪没有显著影响. 这一发现突出了皮下脂肪组织 (SAT) 作为CRC的关键预后因素.
科学领域:
- 在瘤学瘤学.
- 代谢过程中的代谢.
- 流行病学 流行病学
背景情况:
- 脂肪组织分布越来越多地被认为对结直肠癌 (CRC) 患者的治疗结果的影响.
- 内脏和皮下脂肪是了解CRC预后的重点领域.
研究的目的:
- 系统地审查和分析内脏和皮下脂肪和CRC患者生存结果之间的关系.
- 为了确定不同脂肪组织储存在结直肠癌的预后意义.
主要方法:
- 在多个数据库中进行全面的文献搜索,直到2024年10月.
- 对22项研究 (11,954名CRC患者) 的元分析,检查脂肪度量 (VAT,SAT,VAT/SAT比率) 和生存结果 (OS,DFS).
- 使用固定和随机效应模型将危险比率 (HR) 和95%置信区间 (CI) 进行了聚合.
主要成果:
- 较高的皮下脂肪组织 (SAT) 水平与改善的整体存活率 (OS) (HR: 0.77,p < 0.05) 和无病存活率 (DFS) (HR: 0.61,p < 0.05) 显著相关.
- 内脏脂肪组织 (VAT) 与OS或DFS没有显著的相关性.
- 对于增值税/增值税比率和生存结果,没有发现出版偏差.
结论:
- 皮下脂肪率升高与结直肠癌患者的改善OS和DFS有关.
- 皮下脂肪组织 (SAT) 在CRC中表现出比内脏脂肪组织 (VAT) 更大的预后意义.
- 需要进一步的大规模研究来证实这些发现,并调查潜在的机制.
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