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门性交和tenofovir淋浴序列影响结肠直肠分布的艾滋病毒替代品和淋浴:梦想-02

Ruohui Zheng¹, Edward J Fuchs¹, Sridhar Nimmagadda²

¹Division of Clinical Pharmacology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

The Journal of infectious diseases

|May 30, 2025

概括

在此之前已经证实了直肠特诺福维尔淋浴的安全性. 这项研究比较了模拟受体交 (RAI) 之前或之后的淋浴时间,发现时间没有改变淋浴分布,但可能会影响HIV代孕分布.

科学领域:

药理学药理学是指药理学的学科.
传染性疾病传染性疾病
胃肠病学胃肠病学

背景情况:

与男性发生性关系的男性 (MSM) 通过不受保护的接受性交 (RAI) 具有高艾滋病毒感染风险.
一些个人希望进行行为一致的暴露前预防 (PrEP),以尽量减少全身药物暴露.
作为RAI的潜在PrEP选择,开发了一种直肠特诺福维尔淋浴,之前的研究表明其安全性和可接受性.

研究的目的:

为了比较特诺福维尔淋浴和艾滋病毒代用剂的结直肠分布,当淋浴在模拟RAI (sRAI) 之前或之后进行时.
评估淋浴施用时间对药物分发和结直肠内的潜在艾滋病毒暴露部位的影响.

主要方法:

五名参与者接受了两次对照研究访问.
放射性标记的tenofovir淋浴和HIV替代物 (放射性标记的精液) 与sRAI相比,在不同的顺序中被施用.
使用SPECT/CT成像评估结肠直肠分布,并通过血度测量全身药物透性.

主要成果:

淋浴的结直肠分布是相似的,不管它是在sRAI之前还是之后.
与之前相比,当sRAI后施用淋浴时,HIV代用剂的分布进一步扩展到下降结肠.
在服用后20分钟内观察到早期的血诺福维尔峰值,无论服用顺序如何.

结论:

在RAI后施用直肠诺福维尔淋浴可能会改变结肠内的HIV代理物分布,对艾滋病毒感染风险的影响尚不清楚.
快速的血诺福维尔峰值表明,保护的开始可能比以前报告的更快.

关键词:

艾滋病病毒艾滋病病毒艾滋病病毒通过SPECT/CT成像进行成像.门性爱是一种性行为.暴露前的预防暴露前的预防这是直肠微生物杀伤剂.

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