在孤立的REM睡眠行为障碍中,明显的脑缩进展亚型是现象转换的基础.
Stephen Joza1, Aline Delva2, Christina Tremblay3
1The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, H3A 2B4, Canada; Division of Neurology, Department of Medicine, and Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Canada.
EBioMedicine
|May 30, 2025
概括
在像异常REM睡眠行为障碍 (iRBD) 这样的synucleinopathies中存在两种脑缩进展亚型. 皮层第一个亚型增加了勒维体 (DLB) 痴呆症的风险,而两者都会恶化运动症状.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 同核蛋白病变,包括异常REM睡眠行为障碍 (iRBD),帕金森病 (PD) 和患有莱维体 (DLB) 的痴呆症,存在各种临床特征.
- 在iRBD中可以观察到大脑缩模式,但缩的开始和进展仍然不完全理解.
研究的目的:
- 为了研究和描述脑缩进展的时空模式在synucleinopathies.
- 识别缩进展的不同亚型及其临床影响.
主要方法:
- 使用了1276名参与者的多中心队列 (iRBD,PD与RBD,DLB,对照) 与T1加权的MRI和纵向评估.
- 采用基于顶点的皮质表面重建和体积细分来量化缩.
- 应用了亚型和阶段推断 (SuStaIn) 算法来建模缩进展模式.
主要成果:
- 确定了两种不同的缩进展亚型:"皮层第一" (额叶发病) 和"下皮层第一" (边缘发病).
- 这两种亚型都显示出运动症状进展的增加 (MDS-UPDRS-III);认知能力下降与皮质第一亚型的进展阶段有关.
- 分类为亚型的患者更有可能发生转化;皮质第一亚型的iRBD患者与PD相比,患DLB的可能性更高.
结论:
- 在iRBD中存在两种不同的脑缩进展亚型.
- 皮层第一个亚型与患上勒维体痴呆症 (DLB) 的风险增加有关.
- 两种已识别的亚型都与帕金森运动特征的恶化相关,这表明在疾病监测和临床试验分层方面具有实用性.
相关概念视频
REM Sleep Behavior Disorder
431
REM Sleep Behavior Disorder (RBD) is a sleep disorder characterized by the absence of muscle paralysis that normally occurs during the REM phase of sleep. This absence allows individuals to physically act out their dreams, which are often vivid and disturbing. Common behaviors exhibited during episodes include kicking, punching, and yelling. These actions can be dangerous, potentially leading to injuries for the person with RBD or their bed partner.
RBD is significantly associated with...
RBD is significantly associated with...
431
Stages of Sleep
492
Sleep progresses through distinct stages, each characterized by specific brain wave patterns and physiological responses ranging from wakefulness to stages of non-rapid eye movement, known as non-REM, to rapid eye movement, referred to as REM. Understanding these stages helps in recognizing how sleep supports various bodily and cognitive functions.
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
Before sleep begins, in wakefulness, the brain exhibits primarily beta waves, which are high in frequency and low in amplitude, indicating alertness...
492
Sleep-Wake Cycles
1.6K
Sleep is an essential physiological process vital to maintaining overall well-being. The reticular activating system (RAS), a network of neurons in the brainstem, regulates wakefulness and sleep. While it may seem passive, sleep consists of distinct cycles, each with its unique characteristics and functions. Two key sleep phases are non-rapid eye movement (NREM) and rapid eye movement (REM).
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
NREM Sleep
NREM sleep comprises four progressive stages that seamlessly merge:
1.6K
Narcolepsy
205
Narcolepsy is a chronic sleep disorder characterized by pervasive, uncontrolled sleepiness and other sleep disturbances. One of its hallmark symptoms is an abrupt transition to REM sleep upon falling asleep, which causes symptoms typically associated with this phase to occur unexpectedly during wakefulness. These include the following symptoms, which typically last from a minute or two to half an hour.
205
Sleepwalking and Sleep Talking
331
Somnambulism, commonly known as sleepwalking, involves individuals engaging in activities ranging from simple walking to more complex behaviors such as driving. Sleepwalking typically occurs during the slow-wave sleep stages 3 and 4 early in the night when the person is not dreaming, contradicting the myth that sleepwalkers are acting out their dreams.
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
Factors that increase the likelihood of sleepwalking include sleep deprivation and alcohol consumption. Contrary to common beliefs, it is safe...
331
Parkinson's Disease: Overview
723
Neurodegenerative disorders are progressive diseases that cause irreversible damage and loss to neurons in specific brain areas. Examples of these disorders include Parkinson's disease, Alzheimer's disease, Multiple Sclerosis (MS), and Amyotrophic Lateral Sclerosis (ALS). These disorders share characteristics such as proteinopathies, selective neuronal vulnerability, and a complex interplay between genetic and environmental factors. The primary therapeutic goal for these conditions is...
723


