在炎症性肠病中与代谢功能障碍相关的脂肪性肝病:患病率,危险因素,病理生理路径和临床后果
Elena Grueso Navarro1,2,3,4, Alfredo J Lucendo1,2,3,4
1Department of Gastroenterology, Hospital General de Tomelloso, Tomelloso, Spain.
Expert review of clinical immunology
|May 30, 2025
概括
与代谢功能障碍相关的脂肪性肝病 (MASLD) 在炎症性肠病 (IBD) 中很常见. IBD本身是MASLD的风险因素,需要早期检测和综合管理,以获得更好的患者结果.
科学领域:
- 胃肠病学和肝病学 胃肠学和肝病学
- 内部医学 内部医学
- 临床研究 临床研究
背景情况:
- 与代谢功能障碍相关的脂肪性肝病 (MASLD) 是被诊断为炎症性肠病 (IBD) 的患者经常出现的并发症.
- 炎症性肠病 (IBD),特别是克罗恩病,独立地增加患MASLD的风险,并使其进展为肝硬化.
- 肠肝轴调节失调,受微生物群变化,肉症和疾病活动等因素的影响,在IBD队列中对MASLD的发展起着重要作用.
研究的目的:
- 阐明MASLD和IBD之间共享的病理生理机制.
- 分析流行病学数据,风险因素和MASLD在IBD患者的临床后果.
- 为管理同时出现的MASLD和IBD提供基于证据的建议.
主要方法:
- 审查将MASLD与IBD联系在一起的病理生理学方面.
- 对并发症和风险因素的流行病学分析.
- 综合临床数据的结果和管理策略.
主要成果:
- IBD是MASLD进展的独立风险因素,无论代谢综合征的组成部分如何.
- 肠道因素,如肉症,疾病表型,持续时间,活动和微生物群变化是IBD中MASLD的关键贡献者.
- 目前的IBD疗法与MASLD风险没有显著的关联;对生物药物和新型药物的进一步研究是有必要的.
结论:
- 早期检测MASLD对于IBD患者至关重要,因为它增加了并发症,结果较差,死亡率更高.
- 针对MASLD和IBD的个性化和综合管理方法对于改善患者预后至关重要.
- 了解IBD和MASLD之间的相互作用对于优化临床护理和研究方向至关重要.
关键词:
生物制剂 生物制剂 生物制剂克罗恩氏病是什么 克罗恩氏病是什么肠肝轴 肠肝轴 肠肝轴炎症性肠道疾病 炎症性肠道疾病与代谢功能障碍相关的脂肪性肝病.微生物群 (microbiome) 是一个微生物群.非酒精性脂肪性肝病是非酒精性脂肪性肝病.性结肠炎是一种更多相关视频
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