从精确干预到精确的健康
Nicholas J Schork1,2,3,4,5, Laura H Goetz6,7
1The Translational Genomics Research Institute, a part of the City of Hope National Medical Center, Phoenix, AZ (NJS, LHG), USA. nschork@tgen.org.
Nature communications
|May 30, 2025
概括
精准药物提供了量身定制的治疗方法,但它们的确切效果和益处需要更好的预测. 需要采用收集人类数据的新临床试验策略来理解这些先进疗法.
科学领域:
- 药物基因组学 药物基因组学
- 临床药理学 临床药理学
- 翻译医学是一种翻译医学.
背景情况:
- 根据个体资料量身定制的精密药物正在迅速发展.
- 目前的临床前和临床试验方法难以预测干预的准确性.
- 了解作用机制 (MOA),临床效应和个体效用是具有挑战性的.
研究的目的:
- 突出在精准医学研究中需要改进战略的需要.
- 强调收集人类数据的必要性,以便更好地预测.
- 解决当前临床前和临床试验设计的局限性.
主要方法:
- 审查当前的精准医学开发和评估策略.
- 在理解干预影响时识别数据缺口.
- 关于为特定目的建立的临床试验的建议.
主要成果:
- 目前的方法不足以预测精确的MOA,临床效果和精确药物的实用性.
- 对活着的人类的数据对于准确的评估至关重要.
- 需要量身定制的临床试验来收集特定的数据.
结论:
- 改进的临床试验设计对于推进精准医学至关重要.
- 收集全面的人类数据将改善治疗疗效和患者益处的预测.
- 未来的研究必须专注于针对特定目的的试验,以实现精准医学的全部潜力.
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