分层的饮食炎症潜力确定了与老年人认知功能相关的口腔和肠道微生物群差异
Jinxiu Liu1, Yuping Zhang1, Xiuli Li1
1The School of Nursing, Fujian Medical University, Fuzhou, China.
Scientific reports
|May 30, 2025
概括
抗炎饮食对老年人口腔微生物群的多样性和组成产生积极影响. 特定的口腔和肠道微生物与认知功能有关,这表明饮食微生物群相互作用影响大脑健康.
科学领域:
- 微生物组研究的研究.
- 营养科学 营养科学
- 老年学是一门学科.
背景情况:
- 饮食显著影响肠道和口腔微生物组的组成.
- 慢性炎症和微生物失衡与认知障碍有关.
- 饮食中的炎症潜力可以影响宿主微生物群和炎症状态.
研究的目的:
- 调查饮食炎症潜力的对口腔肠道微生物群多样性和组成的影响.
- 探索饮食,微生物组和老年人 (>60岁) 的认知表现之间的关系.
主要方法:
- 利用能量调整的饮食炎症指数 (E-DII) 来评估饮食的炎症性质.
- 采用16S rRNA测序来分析54名参与者的口腔和肠道微生物.
- 通过使用标准测试 (MMSE,MoCA,AVLT-LR,BNT,VFT) 评估认知表现.
主要成果:
- 口腔微生物群的多样性在E-DII组之间有显著差异 (p < 0.05),而肠道微生物群的多样性则没有.
- 抗炎饮食与Saccharimonadia,Corynebacteriaceae,TM7x,Eubacterium_yurii_group和Centipeda的口服丰度增加有关.
- 在抗炎药组中,观察到肠道中霍尔德曼尼拉和海莫菲勒斯的丰度减少.
- 特定的口腔和肠道微生物系与认知得分相关 (p < 0.05).
结论:
- 抗炎饮食促进有益的口腔微生物转移.
- 独特的口腔和肠道微生物组成与老年人的认知功能有关.
- 饮食与微生物组的相互作用是影响认知健康的潜在途径.
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