针对蛋白转化酶亚提利辛/凯类型9的新药与癌症发病率之间的关联
Hsueh-Ju Lu1,2, Shiow-Ing Wang3,4, Wei-Shiou Huang1,2
1Division of Hematology and Oncology, Department of Internal Medicine, Chung Shan Medical University Hospital, No. 110, Sec. 1, Jianguo N. Rd., South District, Taichung, 40201, Taiwan.
Naunyn-Schmiedeberg's archives of pharmacology
|May 30, 2025
概括
与单克隆抗体相比,新型PCSK9抑制剂,包括小干扰RNA (siRNA),可能会降低癌症发病率. 在这项研究中,Inclisiran显示累积癌症发病率较低.
科学领域:
- 心血管医学 心血管医学
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
背景情况:
- 蛋白转化酶子素/素9型 (PCSK9) 抑制剂可以降低LDL胆固醇.
- PCSK9抑制剂包括小干扰RNA (siRNA) 和单克隆抗体.
- PCSK9抑制剂对癌症发病率的影响需要进一步研究.
研究的目的:
- 为了比较用siRNA抑制剂治疗的患者和向PCSK9.9的单克隆抗体治疗的患者的累积癌症发病率.
- 为了评估inclisiran与癌症风险相关的安全概况,与alirocumab/evolocumab相比.
主要方法:
- 使用TrinetX数据库进行回顾性队列研究.
- 包括使用PCSK9向剂的患者,分为siRNA (inclisiran) 和单克隆抗体 (alirocumab/evolocumab) 组.
- 1: 1 倾向性得分匹配以比较不同组之间的癌症发病率.
主要成果:
- 这项研究包括37,226人;其中664人在siRNA组.
- 在匹配后,520天的累计癌症发病率为siRNA的1.39%,单克隆抗体的6.58% (P=.125;aHR=0.463).
- 敏感性分析一致显示,使用siRNA抑制剂的癌症发病率较低.
结论:
- 与alirocumab/evolocumab相比,英克利西兰可能与累积癌症发病率较低有关.
- 这些发现表明PCSK9抑制剂类对癌症风险的潜在差异效应.
- 需要进一步的大规模研究或临床试验来验证这些结果.
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