婴儿后期和学龄儿童的认知发育在新生儿脑病变冷却的儿童中
Sara Rapuc1, Sally Jary2, Ross E Vanderwert3,4
1Population Health Sciences, Bristol Medical School, University of Bristol, Bristol, UK.
Pediatric research
|May 30, 2025
概括
治疗新生儿脑病变 (NE) 的儿童的认知得分可能会在学龄下降,局部剥夺会影响结果. 贝利-III尺度可能低估了这一群体的发育迟缓.
科学领域:
- 新生儿神经学 新生儿神经学
- 发育儿科 发育儿科
- 认知神经科学是一种认知神经科学.
背景情况:
- 由于围产性窒息,新生儿脑病变 (NE) 影响婴儿大脑发育.
- 治疗性低温 (冷却) 是对NE的标准治疗方法.
- 在没有脑的情况下接受NE治疗的儿童需要长期的认知监测.
研究的目的:
- 调查婴儿期和学龄儿童接受NE治疗的儿童的认知得分之间的关联.
- 识别随着时间的推移认知表现的个体变化.
- 探索影响NE后认知结果的因素.
主要方法:
- 研究包括50名出生在>=35周怀孕的儿童,冷却为NE,并且没有脑.
- 在18-21个月时使用贝利婴儿和幼儿发展量表 (Bayley-III) 评估认知 (认知和语言复合分数 - CLC).
- 在6-8岁的儿童使用韦克斯勒智力表 (WISC-IV) 进一步评估认知能力 (全尺度智商 - FSIQ);用于分析CLC和FSIQ关联的线性回归.
主要成果:
- 在CLC和FSIQ之间发现了显著的关联 (系数0.45,R219%).
- 大约45%的儿童从婴儿期到学龄段的认知成绩下降.
- 95的贝利-III值未能识别出63%的FSIQ<85的儿童,这表明对延迟的低估.
结论:
- 贝利-III尺度可能低估了治疗NE的儿童在学龄阶段的认知延迟.
- 在这个群体中,儿童智商似乎受到社会经济因素 (当地贫困) 的影响.
- 纵向监测对于支持NE治疗儿童的认知发展至关重要.
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