高血压和糖尿病对认知障碍的影响:中国的一项病例对照研究
Jing Wu1,2, Xiangjun Yin3, Weiqiang Ji4
1National Center for Chronic and Noncommunicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 100050, China. wujing@chinacdc.cn.
Alzheimer's research & therapy
|May 30, 2025
概括
患有高血压和糖尿病的老年人面临着明显更高的认知障碍风险,包括痴呆症. 这种综合性疾病,高血压和糖尿病 (HD),显示了随着时间的推移对认知健康的累积负面影响.
科学领域:
- 老年学与公共卫生
- 神经科学和神经病学 神经科学和神经病学
- 心血管和代谢疾病 心血管和代谢疾病
背景情况:
- 认知障碍,高血压和糖尿病在老年人中很常见.
- 高血压和糖尿病是已知的认知能力下降的危险因素.
- 联合高血压和糖尿病 (HD) 对认知障碍的累积影响尚不清楚.
研究的目的:
- 调查高血压和糖尿病 (HD) 联合对认知障碍发展的影响.
- 要确定HD对认知障碍的影响是否是累积的.
主要方法:
- 一项涉及13,252名60岁及以上中国人的病例控制研究.
- 使用的倾向得分与选择的参与者匹配.
- 评估了高血压,糖尿病的几率比率 (ORs),以及它们对认知障碍的并发症,使用多重逻辑回归.
主要成果:
- 高血压和糖尿病并发症 (HD) 显著增加了痴呆症 (OR=1.53) 和轻度认知障碍 (MCI) (OR=1.27) 的风险.
- 只有高血压或糖尿病的个体也表现出痴呆和MCI的风险增加.
- 超过5年的HD持续时间显著放大了对MCI和痴呆的影响,随着时间的推移,风险会增加.
结论:
- 患有高血压和糖尿病 (HD) 的老年人患有认知障碍,特别是痴呆症的风险大幅增加.
- 观察到HD对认知障碍有显著的累积影响,这强调了管理这两种疾病的重要性.
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