美国患有急性呼吸道疾病的儿童的腺病毒物种,2016-2019年
Varvara Probst1, Tess Stopczynski2, Justin Z Amarin1
1Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, United States.
Journal of the Pediatric Infectious Diseases Society
|May 31, 2025
概括
人类腺病毒 (HAdV) C 种在患有急性呼吸道疾病 (ARI) 的儿童中引起的住院病例比 HAdV B 种更少. 需要进一步的研究来了解HAdV类型和疾病严重程度.
科学领域:
- 儿童传染病 儿童传染病
- 病毒学 病毒学
- 公共卫生监督是对公共卫生的监督.
背景情况:
- 人类腺病毒 (HAdV) 是儿童急性呼吸道疾病 (ARI) 的常见原因.
- 虽然HAdV-B, -C和 -E物种与ARI有关,但它们的检测频率和在美国症状感染中的作用尚不清楚.
研究的目的:
- 确定在美国ARI儿童中HAdVB和C种的相对检测频率.
- 为了比较感染HAdV-B和HAdV-C的儿童之间的临床特征和住院率.
主要方法:
- 从2016年到2019年,在7家美国儿童医院进行了前性病毒监测研究.
- 18岁以下有ARI症状的儿童的呼吸器样本进行了HAdV测试,并使用实时PCR对阳性样本进行了类型化.
- 在HAdV-B和HAdV-C感染之间比较了临床数据和结果,包括住院和使用氧气.
主要成果:
- 在29381名ARI儿童中,6.3%的HAdV检测呈阳性,HAdV-C (73.0%) 比HAdV-B (22.3%) 更常见.
- 患有HAdV-C的儿童更年轻,更有可能与其他呼吸道病原体同时感染.
- 在对其他病原体进行调整后,与HAdV-B相比,HAdV-C与住院的几率明显降低 (aOR:0.44).
结论:
- 与HAdV-B感染相比,在患有ARI的儿童中,HAdV-C感染与较低的住院率有关.
- 这些发现强调需要进一步研究特定的HAdV类型及其对儿童群体呼吸系统疾病严重程度的贡献.
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