与心理行为干预相关的DNA甲基化变化:一个范围广泛的文献评论
Karen L Saban1, Linda Janusek1, Paula de la Pena1
1Marcella Niehoff School of Nursing, Loyola University Chicago, Maywood, IL, USA.
Biological research for nursing
|May 31, 2025
概括
心理压力影响DNA甲基化 (DNAm),可以通过干预来改变. 本综述总结了从心理行为干预中对DNAm变化的研究,并确定了未来研究的差距.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 心理神经免疫学 心理神经免疫学
- 行为科学 行为科学
背景情况:
- 基因甲基化 (DNAm) 在表观遗传上改变基因表达,影响应激反应.
- 与压力相关的DNAm是可塑的,使其成为心理行为干预的目标.
- 新兴研究调查了像正念和CBT这样的干预措施后的DNAm变化.
研究的目的:
- 进行对检查DNAm因应心理行为干预而发生变化的研究进行范围审查.
- 识别当前的证据,知识差距和该领域的研究建议.
主要方法:
- 基于Arksey和O'Malley (2005) 的范围审查方法.
- 纳入标准:研究血液或唾液DNAm对成人心理行为干预的反应.
- 系统地搜索和综合相关文献.
主要成果:
- 21项研究符合纳入标准,尽管许多研究的强度不足.
- 几项研究报告了DNAm在各种基因中的变化,包括与压力和炎症相关的基因.
- 在参与者健康,干预类型/持续时间,生物样本和DNA分析方法方面观察到显著的异质性.
结论:
- 针对心理行为干预的DNAm的研究是一个不断扩大的研究领域.
- 未来的研究应该解决方法上的局限性,确认生物学意义,并将DNAm变化与临床结果相关联.
- 需要改进的研究设计,以强大地将干预措施,DNAm和健康益处联系起来.
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