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Updated: Oct 15, 2025

Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations
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Heuristic Mining of Hierarchical Genotypes and Accessory Genome Loci in Bacterial Populations

Published on: December 7, 2021

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使用GRATIOSA对细菌转录组和染色体结构数据进行定量空间分析:应用于双超卷域分布

Maïwenn Pineau1, Raphaël Forquet1, Sylvie Reverchon1

  • 1Université de Lyon, INSA Lyon, Université Claude Bernard Lyon 1, CNRS UMR5240, Laboratoire de Microbiologie, Adaptation et Pathogénie, 69621 Villeurbanne, France.

Nucleic acids research
|May 31, 2025
PubMed
概括

我们开发了GRATIOSA,这是一个用于分析空间基因组组织和基因表达的Python包. 它揭示了topoisomerases被招募到高度表达的基因中,对Topoisomerase I和DNA旋转酶具有特定的招募模式.

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Genomic DNA in Prokaryotes

The genome of most prokaryotic organisms consists of double-stranded DNA organized into one circular chromosome in a region of cytoplasm called the nucleoid. The chromosome is tightly wound, or supercoiled, for efficient storage. Prokaryotes also contain other circular pieces of DNA called plasmids. These plasmids are smaller than the chromosome and often carry genes that confer adaptive functions, such as antibiotic resistance.
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