儿童肥胖和代谢综合征中的异生物微生物组-代谢组轴
U Salman1, S M Dabdoub1,2, A Reyes3
1Department of Periodontics, The University of Iowa College of Dentistry and Dental Clinics, Iowa City, IA, USA.
Journal of dental research
|May 31, 2025
概括
儿童肥胖和代谢综合征 (MetS) 改变了口腔微生物群,增加了炎症标志物和与疾病相关的代谢物. 唾液分析显示,这些儿童的口腔环境存在"风险",突出显示了MetS的潜在非侵入性生物标志物.
科学领域:
- 口腔健康研究 口腔健康研究
- 代谢性疾病研究研究.
- 微生物组研究研究.
背景情况:
- 儿童肥胖和代谢综合征 (MetS) 在全球范围内正在上升.
- 这些情况与消极的口腔健康结果有关,但分子联系尚不清楚.
- 研究口腔微生物群,炎症标志物和代谢物可以阐明这些联系.
研究的目的:
- 为了研究口腔微生物组,炎症标志物和肥胖儿童的代谢物和MetS.
- 探索系统代谢健康和口腔健康之间的相互关系.
- 为了确定儿童MetS的潜在的非侵入性唾液生物标志物.
主要方法:
- 招募了76名儿童 (10-17岁) 进入MetS,代谢健康肥胖 (MHO) 和正常体重健康 (NWH) 组.
- 分析了未刺激的唾液,使用16S rRNA对微生物组的测序,对细胞因子/基因的多重测定,以及对代谢物的GC/MS.
- 利用集成的多组学分析 (分散的部分最小平方回归差分分析).
主要成果:
- 与NWH相比,MetS和MHO组显示出不同的口腔微生物组 (例如,减少*Streptococcus*,增加*Aggregatibacter*),尽管临床口腔健康状况相似.
- 在MetS和MHO组中观察到高水平的瘦素,TNF-α,IL-1β,IL-15,以及降低的脂肪内素.
- 在MetS和MHO组中发现了与疾病相关的丰富代谢物 (例如谷氨酸,胆固醇,氨基酸) 和改变的唾液腺素.
结论:
- 患有MetS和MHO的儿童表现出"有风险"的口腔环境,其特点是特定的微生物变化,炎症和代谢变化.
- 唾液变化表明系统代谢状态和口腔健康之间存在潜在的联系.
- 唾液为儿童MetS和相关的口腔健康风险的生物标志物提供了一个有希望的非侵入性来源.
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